| Associated autoimmune diseases in systemic sclerosis define a subset of patients with milder disease: results from 2 large cohorts of European Caucasian patients. | |
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MedLine Citation:
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PMID: 20110522 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To assess the prevalence and potential associations with the systemic sclerosis (SSc) phenotype of additional autoimmune diseases (AID). METHODS: A multicenter study was performed in France and Italy to recruit consecutive European Caucasian patients with SSc systematically assessed for the coexistence of predefined AID known to occur with connective tissue diseases. RESULTS: We recruited 585 French and 547 Italian patients with SSc. Specific AID were found in 114/585 (19%) French and 179/547 (33%) Italians with SSc (p < 0.0001). Sj?gren's syndrome and thyroiditis were the predominant AID in both cohorts (12% for Sj?gren's syndrome and 6% for thyroiditis in the combined populations). The frequency of myositis, primary biliary cirrhosis, rheumatoid arthritis, and systemic lupus erythematosus was low (< 4%) and similar in both cohorts. The coexistence of at least 1 of the AID in the whole cohort was associated in multivariate analysis with the limited cutaneous subtype, the presence of antinuclear antibodies, and a lower prevalence of digital ulcers. CONCLUSION: Our study shows that 21% of this large series of European Caucasian patients with SSc have developed at least 1 AID. This latter condition identified a subset of patients with milder disease. Thus, associations of AID and autoimmune background in SSc have to be considered for further therapeutic and biological investigations in SSc. |
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Authors:
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J?r?me Avouac; Paolo Air?; Philippe Dieude; Paola Caramaschi; Kiet Tiev; Elisabeth Diot; Jean Sibilia; Susanna Cappelli; Brigitte Granel; Alessandra Vacca; Julien Wipff; Olivier Meyer; Andr? Kahan; Marco Matucci-Cerinic; Yannick Allanore |
Publication Detail:
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Type: Journal Article; Multicenter Study Date: 2010-01-28 |
Journal Detail:
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Title: The Journal of rheumatology Volume: 37 ISSN: 0315-162X ISO Abbreviation: J. Rheumatol. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-03 Completed Date: 2010-05-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7501984 Medline TA: J Rheumatol Country: Canada |
Other Details:
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Languages: eng Pagination: 608-14 Citation Subset: IM |
Affiliation:
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Rheumatology A Department, Paris Descartes University, Cochin Hospital, Paris, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antibodies, Antinuclear / blood Autoimmune Diseases / epidemiology* Cohort Studies European Continental Ancestry Group / ethnology* France / epidemiology Humans Italy / epidemiology Middle Aged Multivariate Analysis Phenotype Prevalence Scleroderma, Systemic / complications*, ethnology*, immunology Severity of Illness Index* Sjogren's Syndrome / epidemiology Thyroiditis / epidemiology |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Antinuclear |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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