| Assisted reproductive technology : experience with IVF/ICSI. | |
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MedLine Citation:
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PMID: 15225453 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To analyze success rates of assisted reproduction techniques ART (IVF/ICSI) in couples experiencing subfertility, and factors which may help in predicting treatment outcome. DESIGN: A prospective cohort follow-up study. PLACE AND DURATION OF STUDY: Study was conducted at Concept Fertility Centre, Karachi, between July 1, 2000 and December 31, 2002. SUBJECTS AND METHODS: A cohort of 310 couples undergoing 330 in-vitro fertilization (IVF) and intra cytoplasmic sperm injection (ICSI) cycles were followed for treatment outcomes. Predictor variables included age of women, cause of subfertility, drug regimen used for ovulation induction, day of embryo transfer, and ease of embryo transfer. While outcome variables included rates of fertilization, pregnancy, live birth, miscarriages, multiple pregnancies and ovarian hyperstimulation syndrome (OHSS). RESULTS: The overall pregnancy rate was 35.2 %, while takehome live-birth rate was 25.1%. Treatment cycles which were done for male factor only, had higher probability of success as compared to female factors or for unexplained infertility. Patients who underwent transvaginal ovum pick up and embryo transfer (TVOPU + ET) had an overall pregnancy rate of 29.4% as compared to those who underwent frozen embryo transfer (FET) cycles (22.6%). There was no statistically significant difference between pregnancy rates for ovulation induction with recumbent FSH (rFSH) and HMG (32.7% v 33.6%, p-value 0.87). Quality of embryo transfer was significantly better (33.7%, v 24.2%, p-value 0.042) in patients who conceived. CONCLUSION: Our results are comparable in terms of pregnancy rates, live birth rates and complication rates, to the results reported in international literature. We however, need more data from centres in Pakistan for future reference and research. |
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Authors:
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Javed Haider Rizvi; Nadeem Faiyaz Zuberi; Saifullah Bhatti; Muniza Bana; Sadia Virk; Shahnaz Nadir; Atiya Kidwai; Nasreen Tahir |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of the College of Physicians and Surgeons--Pakistan : JCPSP Volume: 14 ISSN: 1022-386X ISO Abbreviation: J Coll Physicians Surg Pak Publication Date: 2004 May |
Date Detail:
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Created Date: 2004-06-30 Completed Date: 2004-09-24 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9606447 Medline TA: J Coll Physicians Surg Pak Country: Pakistan |
Other Details:
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Languages: eng Pagination: 270-3 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynaecology, The Aga Khan University Hospital, Karachi. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Databases, Factual Embryo Transfer Female Fertilization in Vitro* Humans Male Pakistan Predictive Value of Tests Pregnancy Pregnancy Outcome / epidemiology Sperm Injections, Intracytoplasmic* |
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