Document Detail

Assisted reproductive technologies and birth defects.
MedLine Citation:
PMID:  15904430     Owner:  NLM     Status:  MEDLINE    
In vitro fertilization (IVF) and other assisted reproductive technologies (ART) are effective treatments for infertility and are widely provided at infertility clinics. Although IVF and related ART procedures are generally considered safe, some studies have suggested an excess occurrence of major malformations, low birth-weight and other perinatal complications in babies conceived by ART. Further, it was recently reported that IVF and intracytoplasmic sperm injection (ICSI) are associated with imprinting disorders in the offspring such as Beckwith-Wiedemann syndrome and Angelman syndrome. Here we review the human and animal studies investigating the potential risks of ART, and discuss the need for further investigation.
Kohei Shiota; Shigehito Yamada
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Congenital anomalies     Volume:  45     ISSN:  0914-3505     ISO Abbreviation:  Congenit Anom (Kyoto)     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-05-20     Completed Date:  2005-08-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9306292     Medline TA:  Congenit Anom (Kyoto)     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  39-43     Citation Subset:  IM    
Congenital Anomaly Research Center, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan.
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MeSH Terms
Beckwith-Wiedemann Syndrome / genetics
Congenital Abnormalities / etiology*
Epigenesis, Genetic
Fertilization in Vitro / adverse effects
Fetal Development
Genomic Imprinting
Reproductive Techniques, Assisted / adverse effects*
Sperm Injections, Intracytoplasmic / adverse effects

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