| Assisted reproduction using donated embryos: outcomes from surveillance systems in six countries. | |
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MedLine Citation:
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PMID: 22258660 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUNDEmbryo donation, though less often performed than other assisted reproductive technology (ART), can represent an attractive option for couples who do not wish to discard their embryos remaining after IVF, and for those who cannot or should not conceive naturally. Clinicians and potential participants could benefit from information comparing outcomes of embryo donation with those of other ARTs, in various countries.METHODSWe analyzed outcome information from ART treatment cycles using 2001-2008 data from national surveillance systems in the USA, Canada, the UK, Australia, New Zealand and Finland. We calculated the live birth rate (LBR) with relative risks, the average number of embryos transferred per cycle and the ratio between them (LBR per embryo transferred). We compared outcomes of embryo donation cycles with those for autologous IVF, frozen embryo transfer (FET) and oocyte donation (OD).RESULTSLBRs for embryo donation cycles were 14-33%, compared with 16-28% for autologous FET, 22-35% for autologous IVF and 15-52% for OD. In every country except Australia/New Zealand, and in all countries combined, the LBR for embryo donation approximated that for IVF, with no statistically significant differences in Finland and Canada. The average number of embryos transferred per cycle was 1.5-2.8. The LBR per embryo transferred was 11-12% for donor embryo cycles, compared with 8-11% for autologous FET, 12-15% for autologous IVF and 9-21% for OD.CONCLUSIONSWe found that transfer of donated embryos in these countries yields pregnancy outcomes comparable to those of autologous ART procedures. The variation in outcome rates among countries is not entirely explained by the number of embryos transferred. The relatively high success rates and low costs make embryo donation an attractive family building alternative. |
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Authors:
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Jeffrey A Keenan; Mika Gissler; Reginald Finger |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-17 |
Journal Detail:
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Title: Human reproduction (Oxford, England) Volume: - ISSN: 1460-2350 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8701199 Medline TA: Hum Reprod Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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National Embryo Donation Center, 11126 Kingston Pike, Knoxville, TN 37934, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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