Document Detail

Assisted reproduction treatment in severe myasthenia gravis.
MedLine Citation:
PMID:  18022164     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To report a case of a patient with a severe myasthenia gravis (MG) who underwent controlled ovarian hyperstimulation for assisted conception. DESIGN: Case report and literature review. SETTING: Tertiary infertility center. PATIENT(S): A 40-year-old woman affected by severe MG. INTERVENTION(S): Controlled ovarian hyperstimulation, oocyte retrieval, intracytoplasmic sperm injection (ICSI) procedure for severe oligoastenozoospermia. MAIN OUTCOME MEASURE(S): Short- and long-term effects of assisted reproduction treatment (ART) on the clinical course of MG. RESULT(S): A total of four ICSI cycles were performed. In the third cycle, a pregnancy was achieved, but a spontaneous abortion occurred. No changes in MG therapy were necessary, neither before nor after the treatment. All procedures were well tolerated and no exacerbations of symptoms occurred. By contrast a little, but persistent, improvement of clinical disease course was observed. CONCLUSION(S): This is the first report of a patient with severe MG who underwent ART cycles. Although more patients need to be evaluated, the present case suggests that MG patients should not be excluded a priori from ART.
Giuseppe Ricci; Michela De Santis; Gloria Pagnini; Leo Fischer Tamaro; Elena Giolo; Secondo Guaschino
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2007-11-26
Journal Detail:
Title:  Fertility and sterility     Volume:  90     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-10-13     Completed Date:  2008-11-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  850.e5-8     Citation Subset:  IM    
Assisted Reproduction Unit, Department of Obstetrics and Gynecology, Institute of Child Health, IRCCS Burlo Garofolo and University of Trieste, Trieste, Italy.
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MeSH Terms
Infertility, Female / complications*,  therapy*
Myasthenia Gravis / complications*
Ovulation Induction / methods*
Pregnancy Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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