| Assisted reproduction treatment in severe myasthenia gravis. | |
MedLine Citation:
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PMID: 18022164 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To report a case of a patient with a severe myasthenia gravis (MG) who underwent controlled ovarian hyperstimulation for assisted conception. DESIGN: Case report and literature review. SETTING: Tertiary infertility center. PATIENT(S): A 40-year-old woman affected by severe MG. INTERVENTION(S): Controlled ovarian hyperstimulation, oocyte retrieval, intracytoplasmic sperm injection (ICSI) procedure for severe oligoastenozoospermia. MAIN OUTCOME MEASURE(S): Short- and long-term effects of assisted reproduction treatment (ART) on the clinical course of MG. RESULT(S): A total of four ICSI cycles were performed. In the third cycle, a pregnancy was achieved, but a spontaneous abortion occurred. No changes in MG therapy were necessary, neither before nor after the treatment. All procedures were well tolerated and no exacerbations of symptoms occurred. By contrast a little, but persistent, improvement of clinical disease course was observed. CONCLUSION(S): This is the first report of a patient with severe MG who underwent ART cycles. Although more patients need to be evaluated, the present case suggests that MG patients should not be excluded a priori from ART. |
Authors:
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Giuseppe Ricci; Michela De Santis; Gloria Pagnini; Leo Fischer Tamaro; Elena Giolo; Secondo Guaschino |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2007-11-26 |
Journal Detail:
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Title: Fertility and sterility Volume: 90 ISSN: 1556-5653 ISO Abbreviation: Fertil. Steril. Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-10-13 Completed Date: 2008-11-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: United States |
Other Details:
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Languages: eng Pagination: 850.e5-8 Citation Subset: IM |
Affiliation:
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Assisted Reproduction Unit, Department of Obstetrics and Gynecology, Institute of Child Health, IRCCS Burlo Garofolo and University of Trieste, Trieste, Italy. ricci@burlo.trieste.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Female Humans Infertility, Female / complications*, therapy* Myasthenia Gravis / complications* Ovulation Induction / methods* Pregnancy Pregnancy Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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