| Assisted mechanical ventilation using combined elastic and resistive unloading in cats with severe respiratory failure: effects on gas exchange and phrenic nerve activity. | |
| | |
MedLine Citation:
|
PMID: 10419248 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
This study tests the efficacy of respiratory mechanical unloading as a mode of assisted mechanical ventilation in cats with an intact breathing-control system but severe pulmonary parenchymal injury. Twelve anaesthetized, intubated cats received multiple saline lung lavages so that their total respiratory system compliance decreased from 56.1+/-10.4 to 26.8+/-6.8 ml/kPa (p < 0.001) and their PaO2 fell to 12.38+/-4.71 kPa when 100% O2 was used as inspired gas. They were then exposed to three consecutive 15-min periods of CPAP of 0.5 kPa, respiratory unloading and again CPAP of 0.5 kPa. Unloading was applied with end-expiratory pressure of 0.5 kPa, elastic assistance of 0.03 kPa/ml and resistance compensation of 2.0 kPa/l/s. Arterial blood gases for the CPAP baselines did not differ significantly before and after unloading: pH 7.14+/-0.04 vs. 7.16+/-0.06; PaCO2 8.99+/-2.07 vs. 8.33+/-2.01 kPa; PaO2 12.4+/-4.7 vs. 13.3+/-7.6 kPa. Nor did the baselines differ in terms of tidal volume, respiratory rate and phrenic nerve activity. Unloading increased tidal volume substantially by about 50% and increased respiratory rate slightly, while inspiratory time remained unchanged. PaCO2 fell to 6.63+/-1.57 kPa and pH rose to 7.25+/-0.06. Phrenic nerve activity was significantly down-regulated in terms of total number of impulses and mean impulse frequency in the phrenic nerve burst. These results suggest that combined elastic and resistive unloading may be an effective means of assisted mechanical ventilation in severe respiratory failure of pulmonary parenchymal origin. |
| | |
Authors:
|
A Schulze; A Jonzon; R Sindelar; P Schaller; V Dammann; G Sedin |
Related Documents
:
|
6406408 - Measurement of ventilation using digitally filtered transthoracic impedance. 8346778 - Noninvasive monitoring of respiratory volume. experimental evaluation of a breath monit... 12893458 - Role of parasympathetic (vagal) cardiac control in elevated heart rates of smokers. 1735268 - Postthoracotomy respiratory muscle mechanics during incentive spirometry using respirat... 14568738 - Birthweight, childhood social class, and change in adult blood pressure in the 1946 bri... 3583608 - Protective effect of verapamil on ischaemic renal injury in dogs. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Acta paediatrica (Oslo, Norway : 1992) Volume: 88 ISSN: 0803-5253 ISO Abbreviation: Acta Paediatr. Publication Date: 1999 Jun |
Date Detail:
|
Created Date: 1999-10-21 Completed Date: 1999-10-21 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9205968 Medline TA: Acta Paediatr Country: NORWAY |
Other Details:
|
Languages: eng Pagination: 636-41 Citation Subset: IM; S |
Affiliation:
|
Department of Obstetrics and Gynecology, Klinikum Grosshadern, Ludwig Maximilian University, Munich, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Airway Resistance
/
physiology* Animals Blood Gas Analysis Cats Disease Models, Animal Down-Regulation / physiology Elasticity Lung / physiology Oxygen / blood* Phrenic Nerve / metabolism* Pilot Projects Positive-Pressure Respiration / methods Respiration, Artificial / methods Respiratory Insufficiency / diagnosis, therapy* Respiratory Mechanics / physiology Severity of Illness Index |
| Chemical | |
Reg. No./Substance:
|
7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Clinical symptoms and social factors in a cohort of children spontaneously clearing Helicobacter pyl...
Next Document: Clinically symptomatic central venous catheter-related deep venous thrombosis in newborns.