Document Detail


Assisted hatching is more effective when embryo quality was optimal in previous failed IVF/ICSI cycles.
MedLine Citation:
PMID:  17365461     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Assisted hatching (AH) was developed as a possible solution to repeated implantation failure. The aim of this analysis was to examine the relationship between the morphology of embryos in a previous cycle on outcome in a subsequent cycle with AH. A total of 175 AH cycles performed after previous failed ART without hatching were divided into group A with optimal and group B with suboptimal embryos transferred previously. The groups were similar in terms of demographic and cycle characteristics. In group A, there was a significant improvement (p<0.001) in implantation (28.8 vs 5.1%), clinical pregnancy (41.9 vs 12.1%) and live birth rate (38.5 vs 8.6%) compared with group B. The data suggest that the prognosis for treatment is better if AH is performed after failure despite optimal embryos compared with failure associated with suboptimal embryos and embryo quality is the most significant factor affecting outcome.
Authors:
J Grace; V Bolton; P Braude; Y Khalaf
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology     Volume:  27     ISSN:  0144-3615     ISO Abbreviation:  J Obstet Gynaecol     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-03-16     Completed Date:  2007-05-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8309140     Medline TA:  J Obstet Gynaecol     Country:  England    
Other Details:
Languages:  eng     Pagination:  56-60     Citation Subset:  IM    
Affiliation:
Assisted Conception Unit, King's College London, School of Medicine, Guy's and St Thomas' Hospital, London, UK. jan.grace@gstt.nhs.uk
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MeSH Terms
Descriptor/Qualifier:
Adult
Embryo Disposition*
Female
Humans
Middle Aged
Pregnancy
Pregnancy Outcome*
Reproductive Techniques, Assisted*
Retrospective Studies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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