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Assisted exercise improves bone strength in very low birthweight infants by bone quantitative ultrasound.
MedLine Citation:
PMID:  20796178     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
AIM: To evaluate whether assisted exercise could prevent the development of osteopenia of prematurity, we performed assisted exercise in the study group of very low birthweight (VLBW) premature infants.
METHODS: Sixteen premature infants with birthweight below 1500 g were enrolled in this study and randomly assigned into the exercise (n = 8) and control (n = 8) groups. Assisted exercise involved full extension and flexion range of motion of the upper and lower extremities by a trained nurse with a schedule of 5 days a week for a total of 4 weeks. Bone strength was determined by quantitative ultrasound measurement of tibial bone speed of sound every 2 weeks during the study period.
RESULTS: No difference in gender, birthweight, and gestation age between the exercise and control groups was noted. There was statistically significant less tibial bone speed of sound decrease in the exercise group on the sixth and eighth week of life. During the study period, there were no statistically significant differences in blood biochemistry data, including calcium, phosphorus, magnesium, alkaline phosphatase, osteocalcin and osteoprotegerin, between the two groups.
CONCLUSIONS: This study revealed that early assisted exercise could improve bone strength in very low birthweight infants. The biochemical markers of bone metabolism, osteocalcin and osteoprotegerin, could not be the indicators for early diagnosis of osteopenia of prematurity.
Authors:
Hsiu-Lin Chen; Chia-Ling Lee; Hsing-I Tseng; San-Nan Yang; Rei-Cheng Yang; Hsiao-Ching Jao
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-08-25
Journal Detail:
Title:  Journal of paediatrics and child health     Volume:  46     ISSN:  1440-1754     ISO Abbreviation:  J Paediatr Child Health     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9005421     Medline TA:  J Paediatr Child Health     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  653-9     Citation Subset:  IM    
Copyright Information:
© 2010 The Authors. Journal of Paediatrics and Child Health © 2010 Paediatrics and Child Health Division (Royal Australasian College of Physicians).
Affiliation:
Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
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