Document Detail

Assisted circulation using the TandemHeart during very high-risk PCI of the unprotected left main coronary artery in patients declined for CABG.
MedLine Citation:
PMID:  19360865     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: In a single center experience, we retrospectively evaluated the short-term safety and efficacy of the TandemHeart percutaneous transseptal left ventricular assist (PTVA) system to deliver extracorporeal circulatory support during catheter based treatment of the unprotected left main coronary artery (ULMCA). BACKGROUND: Percutaneous Coronary Intervention (PCI) of the ULMCA usually has been restricted to patients who are hemodynamically unstable or ineligible for coronary artery bypass grafting (CABG). High-risk patients for CABG should be considered at increased risk for PCI as well. In these patients the TandemHeart PTVA System (p-LVAD) may provide a valuable safeguard to reduce procedural risks. METHODS AND RESULTS: Between July 2002 and May 2008 the TandemHeart was used in 9 very high risk patients (Logistic Euro score: 13.64 (7.46-29.67); Syntax score:43 (41-50); Mayo Clinic Risk score (MCRS) 7 (6-8); age: median 65 (range 55-71) undergoing elective PCI for the novo lesions on the ULMCA. All patients were declined for CABG by a heart team. A ''true'' percutaneous insertion technique was used in all patients, technical success rate was 100%. The median (range) time for implementation of circulatory support was 27 min (24-30). A median (range) pump flow up to 4.36 (3.40-5.54) L/min was achieved with significant reduction of left ventricular filling pressures, pulmonary capillary wedge pressure and a small increase of systemic arterial pressures. Median (range) duration of support was 93 min (50.4-102). Successful weaning was achieved in all patients. There was no in hospital death, survival at 6 months was (89%), whereas vascular access site complications were seen in 4 patients (44.4%). CONCLUSIONS: In very high risk PCI, assisted circulation using the TandemHeart-PTVA provides effective, total left ventricular support and may contribute to a reduced procedural risk and improved survival. The rate of device related cardiac and vascular complications was acceptable.
Pascal Vranckx; Carl Johann Schultz; Marco Valgimigli; Janette A Eindhoven; Arie P Kappetein; Evelin S Regar; Ron Van Domburg; Patrick W Serruys
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions     Volume:  74     ISSN:  1522-726X     ISO Abbreviation:  Catheter Cardiovasc Interv     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-08-04     Completed Date:  2009-10-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100884139     Medline TA:  Catheter Cardiovasc Interv     Country:  United States    
Other Details:
Languages:  eng     Pagination:  302-10     Citation Subset:  IM    
Copyright Information:
(c) 2009 Wiley-Liss, Inc.
Department of Cardiac Intensive Care and Interventional Cardiology, Virga Jesseziekenhuis Hartcentrum, Hasselt, Belgium.
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MeSH Terms
Aged, 80 and over
Angioplasty, Transluminal, Percutaneous Coronary* / adverse effects,  instrumentation
Coronary Artery Bypass / contraindications*
Coronary Artery Disease / physiopathology,  therapy*
Extracorporeal Circulation / adverse effects,  instrumentation*
Heart-Assist Devices* / adverse effects
Middle Aged
Patient Care Team
Patient Selection*
Prosthesis Design
Retrospective Studies
Risk Assessment
Time Factors
Treatment Outcome
Comment In:
Catheter Cardiovasc Interv. 2009 Aug 1;74(2):311-2   [PMID:  19642179 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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