Document Detail

Assignment of the human stromelysin 3 (STMY3) gene to the q11.2 region of chromosome 22.
MedLine Citation:
PMID:  1639418     Owner:  NLM     Status:  MEDLINE    
The human stromelysin 3 (STMY3) gene, a new member of the matrix metalloproteinase (MMP) gene family, may contribute to breast cancer cell invasion, and has been localized by in situ hybridization to the long arm of chromosome 22. As demonstrated using a panel of somatic cell hybrids, the STMY3 gene is in band 22q11.2, in close proximity to the BCR gene involved in chronic myeloid leukemia, but far from the (11;22) translocation breakpoint observed in Ewing sarcoma. This position differs from that reported on chromosomes 11 and 16 for the other MMP genes, suggesting that stromelysin 3 could be a member of a new MMP subfamily.
A Levy; J Zucman; O Delattre; M G Mattei; M C Rio; P Basset
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Genomics     Volume:  13     ISSN:  0888-7543     ISO Abbreviation:  Genomics     Publication Date:  1992 Jul 
Date Detail:
Created Date:  1992-08-28     Completed Date:  1992-08-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8800135     Medline TA:  Genomics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  881-3     Citation Subset:  IM    
Unité 242 de Physiopathologie Chromosomique, INSERM, Hôpital d'Enfants, Marseille, France.
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MeSH Terms
Breast Neoplasms / genetics
Chromosome Mapping
Chromosomes, Human, Pair 22*
Hybrid Cells
Matrix Metalloproteinase 11
Metalloendopeptidases / genetics*
Multigene Family
Nucleic Acid Hybridization
Reg. No./Substance:
EC 3.4.24.-/Matrix Metalloproteinase 11; EC 3.4.24.-/Metalloendopeptidases

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