| Assignment of the chicken tyrosine hydroxylase gene to chromosome 6 by FISH. | |
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MedLine Citation:
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PMID: 1351832 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The gene for tyrosine hydroxylase, the first and rate-limiting enzyme in the biosynthetic pathway of catecholamine neurotransmitters, has been localized in situ to chromosome 6 in the chicken. It is the first DNA marker to be reported for this telocentric macrochromosome. Use of a 45-kb biotinylated chicken-specific cosmid probe and a sensitive fluorescent detection system proved to be highly efficient, with over 90% of metaphases showing positive hybridization signals on one or (usually) both chromosome 6 homologs, in physically mapping this single-gene locus. |
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Authors:
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M Dominguez-Steglich; A Carrier; C Auffray; M Schmid |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cytogenetics and cell genetics Volume: 60 ISSN: 0301-0171 ISO Abbreviation: Cytogenet. Cell Genet. Publication Date: 1992 |
Date Detail:
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Created Date: 1992-07-29 Completed Date: 1992-07-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0367735 Medline TA: Cytogenet Cell Genet Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 138-9 Citation Subset: IM |
Affiliation:
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Department of Human Genetics, University of Würzburg, FRG. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chickens / genetics* Chromosome Mapping* Cosmids / genetics DNA Probes / genetics Fluorescence Nucleic Acid Hybridization Tyrosine 3-Monooxygenase / genetics* |
| Chemical | |
Reg. No./Substance:
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0/DNA Probes; EC 1.14.16.2/Tyrosine 3-Monooxygenase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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