Document Detail

Assignment of the chicken tyrosine hydroxylase gene to chromosome 6 by FISH.
MedLine Citation:
PMID:  1351832     Owner:  NLM     Status:  MEDLINE    
The gene for tyrosine hydroxylase, the first and rate-limiting enzyme in the biosynthetic pathway of catecholamine neurotransmitters, has been localized in situ to chromosome 6 in the chicken. It is the first DNA marker to be reported for this telocentric macrochromosome. Use of a 45-kb biotinylated chicken-specific cosmid probe and a sensitive fluorescent detection system proved to be highly efficient, with over 90% of metaphases showing positive hybridization signals on one or (usually) both chromosome 6 homologs, in physically mapping this single-gene locus.
M Dominguez-Steglich; A Carrier; C Auffray; M Schmid
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cytogenetics and cell genetics     Volume:  60     ISSN:  0301-0171     ISO Abbreviation:  Cytogenet. Cell Genet.     Publication Date:  1992  
Date Detail:
Created Date:  1992-07-29     Completed Date:  1992-07-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0367735     Medline TA:  Cytogenet Cell Genet     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  138-9     Citation Subset:  IM    
Department of Human Genetics, University of Würzburg, FRG.
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MeSH Terms
Chickens / genetics*
Chromosome Mapping*
Cosmids / genetics
DNA Probes / genetics
Nucleic Acid Hybridization
Tyrosine 3-Monooxygenase / genetics*
Reg. No./Substance:
0/DNA Probes; EC 3-Monooxygenase

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