| Assessment of working skeletal muscle oxygenation in patients with chronic heart failure. | |
| | |
MedLine Citation:
|
PMID: 7900619 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Patients with chronic heart failure (CHF) are frequently limited by muscle fatigue resulting from impaired skeletal muscle blood flow. Accordingly, we assessed working skeletal muscle oxygenation in such patients using near-infrared (NIR) spectroscopy. Nine normal subjects (mean age 52 years) and 12 patients with CHF (mean age 60 years) were studied. NIR spectroscopy was used to monitor relative changes in oxygenated hemoglobin (Hb) and myoglobin (Mb) (oxy Hb/Mb), deoxygenated Hb and Mb (deoxy Hb/Mb), and total (oxy + deoxy) Hb and Mb (total Hb/Mb) contents in the vastus lateralis muscle at rest, during warm-up (0 W, 30 cycles/min for 3 min), incremental maximal supine bicycle exercise (ramp protocol, 15 W/min, 50 cycles/min), and recovery. At peak exercise the patients exhibited reduced heart rate, systolic blood pressure, peak exercise oxygen consumption (VO2; 15 +/- 3.0 ml/kg/min vs 32 +/- 8.5 ml/kg/min), and workload (99 +/- 23.4 W vs 183 +/- 68.4 W) as compared with the normal subjects. The respiratory quotient was comparable in both groups. In the normal subjects, oxy Hb/Mb was increased from the warm-up period to the early phase of exercise, followed by a progressive decrease to peak exercise. In the recovery phase, oxy Hb/Mb was increased abruptly. For these patients, change in oxy Hb/Mb followed a pattern similar to that seen in normal subjects, and oxy Hb/Mb was decreased earlier in contrast to that in the normal subjects. There was a significant difference in the change of oxy Hb/Mb during warm-up, early phase exercise, and recovery between the two groups.(ABSTRACT TRUNCATED AT 250 WORDS) |
| | |
Authors:
|
S Matsui; N Tamura; T Hirakawa; S Kobayashi; N Takekoshi; E Murakami |
Related Documents
:
|
8041679 - Exercise training in patients with congestive heart failure. how to achieve benefits sa... 1514499 - Ventilatory mechanisms of exercise intolerance in chronic heart failure. 10527769 - Exercise skeletal muscle blood flow is related to peripheral microvascular stiffness in... 3795459 - Exercise capacity of patients with post-operative tetralogy of fallot. 10424509 - Exercise-induced rise in arterial potassium in patients with chronic heart failure. 14658999 - Does physical training increase insulin sensitivity in chronic heart failure patients? 23187319 - Variability of blood lactate during and between given constant prolonged cycling power. 913359 - Electrocardiographic abnormalities in hypothyroidism before and after exercise. 15076789 - Attitudes toward obese individuals among exercise science students. |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: American heart journal Volume: 129 ISSN: 0002-8703 ISO Abbreviation: Am. Heart J. Publication Date: 1995 Apr |
Date Detail:
|
Created Date: 1995-04-27 Completed Date: 1995-04-27 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 690-5 Citation Subset: AIM; IM |
Affiliation:
|
Department of Cardiology, Kanazawa Medical University, Ishikawa, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Exercise Test
/
methods Exercise Tolerance / physiology* Heart Failure / metabolism*, physiopathology Hemoglobins / metabolism Humans Male Middle Aged Muscle Contraction / physiology Muscle, Skeletal / blood supply, metabolism* Myoglobin / analogs & derivatives, metabolism Oxygen Consumption / physiology* Oxyhemoglobins / metabolism Pulmonary Gas Exchange / physiology Regional Blood Flow / physiology Spectrophotometry, Infrared / methods |
| Chemical | |
Reg. No./Substance:
|
0/Hemoglobins; 0/Myoglobin; 0/Oxyhemoglobins; 0/deoxymyoglobin; 0/oxymyoglobin; 9008-02-0/deoxyhemoglobin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Altered diastolic [Ca2+]i handling in human ventricular myocytes from patients with terminal heart f...
Next Document: Relation between diastolic left ventricular function and myocardial blood volume during adenosine-in...