| Assessment of vasoactive metabolites released from the isolated guinea pig during heart hypoxia and beta-adrenergic stimulation. | |
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MedLine Citation:
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PMID: 6269527 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Two isolated guinea pig hearts (H1, H2) were perfused in series in order to bioassay in the recipient heart (H2) the release of vasoactive metabolites. Due to an effective reoxygenation system transit time between H1 and H2 as only 20 sec. Hypoxic perfusion (30% O2) of H1 caused relaxation of the coronary vessels of H2, and this effect could be completely abolished by adenosine deaminase. Similar results were obtained when H1 was stimulated by isoproterenol while H2 was protected by propranolol. From our findings it is concluded that adenosine is the primary vasodilating substance released by the heart into the coronary circulation. |
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Authors:
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J Schrader; H Bardenheuer |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Basic research in cardiology Volume: 76 ISSN: 0300-8428 ISO Abbreviation: Basic Res. Cardiol. Publication Date: 1981 Jul-Aug |
Date Detail:
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Created Date: 1981-11-18 Completed Date: 1981-11-18 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0360342 Medline TA: Basic Res Cardiol Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 365-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine
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metabolism*,
physiology Animals Anoxia / metabolism* Coronary Circulation* Guinea Pigs Isoproterenol / pharmacology Myocardium / metabolism* Propranolol / pharmacology Receptors, Adrenergic, beta / drug effects Vasodilation* |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Adrenergic, beta; 525-66-6/Propranolol; 58-61-7/Adenosine; 7683-59-2/Isoproterenol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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