Document Detail


Assessment of validity and predictability of the FiO2-SpO2 transfer-function in preterm infants.
MedLine Citation:
PMID:  24875387     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
In this paper an investigation of the gain, delay, and time-constant parameters of the transfer function describing the relation between fraction of inspired oxygen (FiO2) and oxygen saturation in the blood (SpO2) in preterm infants is presented. The parameters were estimated following FiO2 adjustments and goodness of fit was used to assess the validity of the model when using an assumed first-order transfer function. For responses identified to be first-order, the estimated parameters were then clustered to identify areas where they tended to be concentrated. Each group described an operating region of the transfer function; thus, predicting the right operating region could potentially assist a range-based robust inspired oxygen controller to provide more optimal control by adapting itself to different clusters. Accordingly, the samples were assigned labels based on their cluster associations and 14 features available at the time of each adjustment were used as inputs to an artificial neural network to classify the clustered samples. The validity study suggested that 37% of the adjustments were followed by first-order responses. Prediction studies on the first-order responses indicated that the clusters could be predicted with an average accuracy of 64% when the parameters were divided into two groups.
Authors:
O Sadeghi Fathabadi; T J Gale; K Lim; B P Salmon; K I Wheeler; J C Olivier; P A Dargaville
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-5-29
Journal Detail:
Title:  Physiological measurement     Volume:  35     ISSN:  1361-6579     ISO Abbreviation:  Physiol Meas     Publication Date:  2014 May 
Date Detail:
Created Date:  2014-5-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9306921     Medline TA:  Physiol Meas     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1425-1437     Citation Subset:  -    
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