| Assessment of the tumor microenvironment in cervix cancer using dynamic contrast enhanced CT, interstitial fluid pressure and oxygen measurements. | |
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MedLine Citation:
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PMID: 15990015 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Interstitial fluid pressure (IFP) and oxygen (pO(2)) measurements are prognostic factors in cervical cancer. The purpose of this study was to determine the relationship between IFP and oxygenation and parameters derived from dynamic contrast-enhanced computed tomography (DCE-CT). METHODS AND MATERIALS: Dynamic contrast-enhanced computed tomography was performed in 32 patients with cervical cancer before radiation therapy. Images were acquired during intravenous contrast injection at 1 per s for 120 s and 1 per 15 s for 60 s. DCE-CT was analyzed using CT Perfusion 3 software (GE Medical Systems) to derive tumor blood flow (BF), permeability surface area product, blood volume, and mean transit time. Further analysis was performed to obtain relative peak enhancement, residual enhancement at 3 min after contrast injection (RE), time to peak and initial slope. Nodal status and tumor size were assessed with MRI. From in vivo IFP (n = 31) and pO(2) (n = 31) tumor measurements median pO(2) (mO(2)), percentage measurements less than 5 mm Hg (HP5) and mean IFP values were calculated. RESULTS: There was a positive correlation between BF and mO(2) (r = 0.47, p = 0.007) and between RE and HP5 (r = 0.39, p = 0.03). There was no correlation between IFP and DCE-CT parameters. CONCLUSION: There is a moderately positive, correlation between tumor oxygenation and BF as well as RE and HP5. Further study is required to determine if DCE-CT parameters are useful predictors of tumor behavior in cervical cancer. |
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Authors:
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Masoom A Haider; Michael Milosevic; Anthony Fyles; Igor Sitartchouk; Ivan Yeung; Elizabeth Henderson; Gina Lockwood; Ting Y Lee; Timothy P L Roberts |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of radiation oncology, biology, physics Volume: 62 ISSN: 0360-3016 ISO Abbreviation: Int. J. Radiat. Oncol. Biol. Phys. Publication Date: 2005 Jul |
Date Detail:
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Created Date: 2005-07-01 Completed Date: 2005-08-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7603616 Medline TA: Int J Radiat Oncol Biol Phys Country: United States |
Other Details:
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Languages: eng Pagination: 1100-7 Citation Subset: IM |
Affiliation:
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The Joint Department of Medical Imaging, University Health Network and Mount Sinai Hospital, University of Toronto, Princess Margaret Hospital, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Extracellular Fluid
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physiology* Female Humans Oxygen / analysis* Pressure Tomography, X-Ray / methods Uterine Cervical Neoplasms / blood supply*, metabolism*, pathology |
| Chemical | |
Reg. No./Substance:
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7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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