| Assessment of tumor antigen-loaded solid lipid nanoparticles as an efficient delivery system for dendritic cell engineering. | |
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MedLine Citation:
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PMID: 23311961 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Aim: The work attempts to overcome tumor-associated immune tolerance using a surface-modified solid lipid nanoparticle (SLNP) delivery system for dendritic cell (DC) immunotherapy. Materials & methods: Different formulations of SLNPs (SLNPs-alone, cationic-SLNPs and mannosylated-SLNPs) were prepared using tumor cell lysates. Prepared nanoparticles were characterized and their ability to activate DCs to induce a tumor cell-specific response was assessed. Results: SLNPs induced a strong phagocytic signal to DCs without any significant toxicity. Comparatively, mannosylated-SLNPs evoked an optimum and effective cell-mediated immune response with no significant toxicity. Conclusion: Surface-modified SLNPs may play a pivotal role in designing a clinically translatable DC-based immunotherapy for gastrointestinal malignancies. This novel approach may also facilitate the treatment of residual disease, following standard therapy. Original submitted 9 February 2012; Revised submitted 19 August 2012. |
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Authors:
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Arpit Bhargava; Dinesh Mishra; Saba Khan; Subodh K Varshney; Smita Banerjee; Pradyumna K Mishra |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-14 |
Journal Detail:
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Title: Nanomedicine (London, England) Volume: - ISSN: 1748-6963 ISO Abbreviation: Nanomedicine (Lond) Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101278111 Medline TA: Nanomedicine (Lond) Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Biotechnology, Dr Hari Singh Gour Central University, Sagar, India. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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