Document Detail


Assessment of tissue repair in full thickness chondral defects in the rabbit using magnetic resonance imaging transverse relaxation measurements.
MedLine Citation:
PMID:  18161814     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this study was to determine if the noninvasive and nondestructive technique of magnetic resonance imaging could be used to quantify the amount of repair tissue that fills surgically-induced chondral defects in the rabbit. Sixteen 4-mm diameter full-thickness chondral defects were created. A photopolymerizable hydrogel was used to seal the defects as a treatment modality. At 5 weeks, the animals were sacrificed and the distal femur was subjected to MRI analyses at high field (9.4 T). The transverse relaxation time (T(2)) in each defect was measured. Histology and histomorphometric analysis were used to quantify the amount of repair tissue that filled each defect. The relationship between T(2) and percent tissue fill was found to fit well to a negatively sloped, linear model. The linear (Pearson's product-moment) correlation coefficient was found to be r = -0.82 and the associated coefficient of determination was r(2) = 0.67. This correlation suggests that the MRI parameter T(2) can be used to track changes in the amount of repair tissue that fills cartilage defects. This would be especially useful in in vivo cartilage tissue engineering studies that attempt to determine optimal biomaterials for scaffold design.
Authors:
Sharan Ramaswamy; Ilksen Gurkan; Blanka Sharma; Brett Cascio; Kenneth W Fishbein; Richard G Spencer
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural    
Journal Detail:
Title:  Journal of biomedical materials research. Part B, Applied biomaterials     Volume:  86     ISSN:  1552-4981     ISO Abbreviation:  J. Biomed. Mater. Res. Part B Appl. Biomater.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-07-16     Completed Date:  2008-09-17     Revised Date:  2011-09-26    
Medline Journal Info:
Nlm Unique ID:  101234238     Medline TA:  J Biomed Mater Res B Appl Biomater     Country:  United States    
Other Details:
Languages:  eng     Pagination:  375-80     Citation Subset:  IM    
Copyright Information:
(c) 2007 Wiley Periodicals, Inc.
Affiliation:
National Institute on Aging, National Institutes of Health, Laboratory of Clinical Investigation, Gerontology Research Center, Room 4D-08, 5600 Nathan Shock Drive, Baltimore, Maryland 21224, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cartilage Diseases / diagnosis*,  surgery
Cartilage, Articular / pathology,  surgery*
Hydrogels / therapeutic use*
Magnetic Resonance Imaging / methods*
Rabbits
Tissue Engineering / methods
Wound Healing*
Chemical
Reg. No./Substance:
0/Hydrogels

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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