Document Detail


Assessment of thyroid function during pregnancy: the advantage of self-sequential longitudinal reference intervals.
MedLine Citation:
PMID:  22291805     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: To evaluate clinical value of a new self-sequential longitudinal reference intervals of thyroid function during pregnancy.
MATERIAL AND METHODS: WE ESTABLISHED TWO DIFFERENT SERIES OF REFERENCE INTERVALS: self-sequential longitudinal reference intervals (SLRI) and general gestation-specific reference intervals (GSRI). For SLRI, the serum of 301 cases were collected five times in every case throughout the gestation. For GSRI, A total of 1455 subjects included in the study. We collected the serum respectively at various trimesters. We used TSH of both reference intervals to screen 1744 pregnant women, and compared the percentage of potential misclassification.
RESULTS: Both SLRI and GSRI differed substantially from that for non-pregnant women (p < 0.05). There are similar fluctuations of serum TSH, FT4 and TPO-Ab during normal pregnancy. Although there were no significant differences in most reference intervals between SLRI and GSRI. But the IQR of SLRI were usually smaller than GSRI , especially in 1(st) trimester. Two hundred and fifty two women (14.4%) at various trimesters whose serum TSH concentration was within SLRI would be misclassified, while 23 women (1.3%) with a TSH concentration outside limit would not be identified. 0.11-3.84% women would got thyroid diseases during pregnancy. Subclinical hypothyroidism is most common maternal thyroid disorders.
CONCLUSIONS: The SLRI can reflected the changes of thyroid function realistically, and can be used to decrease the percentage of potential misclassification of thyroid dysfunction during pregnancy. Screening for thyroid dysfunction of pregnant women is recommended and important.
Authors:
Qiu-Wei Wang; Bin Yu; Rui-Ping Huang; Fang Cao; Zi-Qiang Zhu; Da-Cheng Sun; Hong Zhou
Related Documents :
8627925 - An unusual coccidian parasite causing pneumonia in a northern cardinal (cardinalis card...
2994695 - Influence of beta-receptor stimulation on catecholamine and phospholipid concentrations...
23250795 - Lectin-based analysis of fucose and sialic acid expressions on human amniotic iga durin...
11493495 - Do physiological changes in pregnancy change defibrillation energy requirements?
11966475 - Management and outcome of pregnancy in women with thrombophylic disorders and past cere...
12796895 - Evaluation of biophysical fetal assessment in high-risk pregnancy to assess ultrasound ...
Publication Detail:
Type:  Journal Article     Date:  2011-09-02
Journal Detail:
Title:  Archives of medical science : AMS     Volume:  7     ISSN:  1896-9151     ISO Abbreviation:  Arch Med Sci     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2012-01-31     Completed Date:  2012-10-02     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101258257     Medline TA:  Arch Med Sci     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  679-84     Citation Subset:  -    
Affiliation:
Changzhou Women and Children Health Hospital to Nanjing Medical University, Jiangsu Province, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Incidence of colorectal cancer in Poland in 1999-2008.
Next Document:  Patient-controlled epidural analgesia after Caesarean section: levobupivacaine 0.15% versus ropivaca...