Document Detail

Assessment of thoracic gas volume by low-frequency ambient pressure changes in children.
MedLine Citation:
PMID:  3181405     Owner:  NLM     Status:  MEDLINE    
The validity of a new method for measuring thoracic gas volume (TGV) was studied in 69 children, 4-16 yrs old, including twelve normal children and 57 children with an obstructive (n = 38) or restrictive (n = 19) respiratory disease. The method consisted of applying very slow (0.05 Hz) sinusoidal variations of ambient pressure around the body (delta Pam = 40 cmH2O peak to peak) and studying the relationship between delta Pam and the resulting gas displacement at the mouth (Vaw): TGVapc = Vaw/delta Pam.cos phi, where PB is barometric minus alveolar water vapour pressure and phi the phase angle between Pam and Vaw. Functional residual capacities derived from TGVapc (FRCapc) were compared to the values obtained by plethysmography (FRCplet) and by helium dilution (FRCdil). FRCapc did not differ significantly from FRCplet in either the entire group (1.75 +/- 0.62 l vs 1.79 +/- 0.45 l) or in the patient subgroups. However, with the new method a trend to slightly lower FRCs was seen in patients with the most obstruction (p less than 0.05). FRCdil was significantly lower than both FRCapc and FRCplet (p less than 0.001), particularly in children with obstruction. Significant correlations were found between the three methods (p less than 0.001). On the other hand, the method investigated requires that the subject breathe very regularly for a period of several minutes. This was rarely achieved, so that the reproducibility of the measurements was unacceptably low. At present, the method cannot be recommended for routine use in 4-16 yr old children.
R Peslin; F Marchal; C Gallina; M Oswald; J P Crance
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The European respiratory journal     Volume:  1     ISSN:  0903-1936     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  1988 Jul 
Date Detail:
Created Date:  1988-12-22     Completed Date:  1988-12-22     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  594-9     Citation Subset:  IM    
Unité 14 INSERM de Physiopathologie Respiratoire, Vandoeuvre-les-Nancy, France.
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MeSH Terms
Child, Preschool
Functional Residual Capacity
Lung Diseases, Obstructive / diagnosis
Lung Volume Measurements / methods*
Plethysmography, Whole Body
Work of Breathing

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