Document Detail

Assessment of target-organ damage in adolescent white-coat and sustained hypertensives.
MedLine Citation:
PMID:  20616755     Owner:  NLM     Status:  MEDLINE    
AIMS AND SCOPE: The aim of the present study was to assess whether a difference exists between intima-media thickness and the left ventricular mass index in healthy nonhypertensive, white-coat hypertensive and sustained hypertensive adolescents.
PATIENTS AND METHODS: Fifty-nine normotensive and 120 hypertensive adolescents were enrolled in our study. Hypertensive patients were classified into white-coat hypertension (WCH) and sustained hypertension groups based on 24-h ambulatory blood pressure measurements. Both normotensive and hypertensive individuals underwent routine laboratory tests, intima-media thickness measurements on the common carotid arteries and transthoracic echocardiography to measure the left ventricular mass index (LVMI).
RESULTS: Intima-media thickness was higher both in WCH and sustained hypertension compared with healthy normotensive individuals (controls: 0.048 ± 0.01 cm, WCH: 0.056 ± 0.01 cm, sustained hypertension: 0.054 ± 0.012 cm, both P < 0.001 compared with controls, nonsignificant difference between the two hypertensive groups). There was no difference between the LVMI of control individuals and WCH (LVMI: 35.5 ± 10.3 g/m and 37.7 ± 11.2 g/m respectively, P = 0.87). LVMI in sustained hypertension group (LVMI: 44.1 ± 14.1 g/m) was significantly higher both compared with WCH (P < 0.05), and healthy adolescents (P < 0.001).
CONCLUSION: Target-organ damage develops in a stepwise fashion in adolescent hypertension. An increased intima-media thickness can be demonstrated not only in the sustained but also in the white-coat form of adolescent hypertension.
Dénes Páll; Mária Juhász; Szabolcs Lengyel; Csilla Molnár; György Paragh; Béla Fülesdi; Eva Katona
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of hypertension     Volume:  28     ISSN:  1473-5598     ISO Abbreviation:  J. Hypertens.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-16     Completed Date:  2011-01-18     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  2139-44     Citation Subset:  IM    
First Department of Medicine, University of Debrecen, Debrecen, Hungary.
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MeSH Terms
Blood Pressure / physiology
Blood Pressure Monitoring, Ambulatory
Carotid Arteries / pathology*,  ultrasonography
Case-Control Studies
Heart Ventricles / pathology*,  ultrasonography
Hypertension / epidemiology,  pathology*,  physiopathology
Office Visits*
Tunica Intima / pathology*,  ultrasonography
Tunica Media / pathology*,  ultrasonography

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