| Assessment of target-organ damage in adolescent white-coat and sustained hypertensives. | |
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MedLine Citation:
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PMID: 20616755 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PATIENTS AND METHODS: Fifty-nine normotensive and 120 hypertensive adolescents were enrolled in our study. Hypertensive patients were classified into white-coat hypertension (WCH) and sustained hypertension groups based on 24-h ambulatory blood pressure measurements. Both normotensive and hypertensive individuals underwent routine laboratory tests, intima-media thickness measurements on the common carotid arteries and transthoracic echocardiography to measure the left ventricular mass index (LVMI). RESULTS: Intima-media thickness was higher both in WCH and sustained hypertension compared with healthy normotensive individuals (controls: 0.048 ± 0.01 cm, WCH: 0.056 ± 0.01 cm, sustained hypertension: 0.054 ± 0.012 cm, both P < 0.001 compared with controls, nonsignificant difference between the two hypertensive groups). There was no difference between the LVMI of control individuals and WCH (LVMI: 35.5 ± 10.3 g/m and 37.7 ± 11.2 g/m respectively, P = 0.87). LVMI in sustained hypertension group (LVMI: 44.1 ± 14.1 g/m) was significantly higher both compared with WCH (P < 0.05), and healthy adolescents (P < 0.001). CONCLUSION: Target-organ damage develops in a stepwise fashion in adolescent hypertension. An increased intima-media thickness can be demonstrated not only in the sustained but also in the white-coat form of adolescent hypertension. |
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Authors:
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Dénes Páll; Mária Juhász; Szabolcs Lengyel; Csilla Molnár; György Paragh; Béla Fülesdi; Eva Katona |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of hypertension Volume: 28 ISSN: 1473-5598 ISO Abbreviation: J. Hypertens. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-16 Completed Date: 2011-01-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: England |
Other Details:
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Languages: eng Pagination: 2139-44 Citation Subset: IM |
Affiliation:
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First Department of Medicine, University of Debrecen, Debrecen, Hungary. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Blood Pressure / physiology Blood Pressure Monitoring, Ambulatory Carotid Arteries / pathology*, ultrasonography Case-Control Studies Echocardiography Female Heart Ventricles / pathology*, ultrasonography Humans Hypertension / epidemiology, pathology*, physiopathology Male Office Visits* Prevalence Tunica Intima / pathology*, ultrasonography Tunica Media / pathology*, ultrasonography |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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