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Assessment of synovitis to predict bone erosions in rheumatoid arthritis.
MedLine Citation:
PMID:  22859922     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Although rheumatoid arthritis (RA) is traditionally considered as the prototype of destructive arthritis, the course of the disease varies considerably, with some patients experiencing more rapid progression of joint damage and disability than others. Given the increasing availability of treatment targets and options, timely recognition of individual's outcomes could allow therapeutic allocation according to personalized benefit-risk profiles. Research efforts are thus increasingly focused at discovering predictive markers that could identify patients with aggressive, rapidly progressive disease and poor prognosis. As joint destruction in RA is the result of the cumulative burden of inflammation, variables reflecting the severity of synovitis and its persistence over time might refine our ability to build early prognostic algorithms. The goal of this article is to review the clinical implications of the assessment of synovitis in relation to radiographic outcomes. Traditional and novel assessment tools will be discussed, including clinical measures, imaging techniques and tissue biomarkers. Achievements in the field of synovial tissue analysis and peripheral blood biomarkers of synovitis represent only the first steps of ongoing progress, which still need to be integrated into the phenotypic heterogeneity of RA.
Authors:
Serena Bugatti; Antonio Manzo; Roberto Caporali; Carlomaurizio Montecucco
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Therapeutic advances in musculoskeletal disease     Volume:  4     ISSN:  1759-7218     ISO Abbreviation:  Ther Adv Musculoskelet Dis     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-08-03     Completed Date:  2012-08-23     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  101517322     Medline TA:  Ther Adv Musculoskelet Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  235-44     Citation Subset:  -    
Affiliation:
Division of Rheumatology, University of Pavia School of Medicine, IRCCS Policlinico San Matteo Fondation, Piazzale Golgi 2, 27100 Pavia, Italy.
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