Document Detail

Assessment of sublingual isosorbide dinitrate and intracoronary nifedipine during ergonovine provocation.
MedLine Citation:
PMID:  6666236     Owner:  NLM     Status:  MEDLINE    
In 37 patients with suspected vasospastic angina diagnostic ergonovine testing was used as a method of analysing the efficacy of sublingual ISDN in comparison with sublingual and intracoronary nifedipine on coronary luminal diameter, left ventricular ejection fraction, aortic blood pressure, heart rate and left ventricular end-diastolic pressure. 10 mg of sublingual ISDN counteracted the ergonovine effects on left ventricular pump function and hemodynamics. The luminal diameter of the epicardial coronary arteries increased from 3.5 +/- 0.8 to 4.9 +/- 0.8 mm. 20 mg of sublingual nifedipine did not change the coronary luminal diameter within 8-10 minutes after the ergonovine test. After administration of 0.1 mg of nifedipine into the right and left coronary artery the luminal diameters increased in the same range as after sublingual ISDN. Whereas the aortic blood pressure decreased after intracoronary nifedipine from 170 +/- 23 to 153 +/- 27 mmHg with a concomitant increase in heart rate, no effect on the left ventricular pump function could be assessed. In the model of ergonovine testing ISDN has shown itself as a potent drug in releasing the ergonovine effects. Sublingual ISDN is as potent as intracoronary nifedipine in releasing the ergonovine-induced reduction of coronary luminal diameters and more potent in counteracting the ergonovine effects concerning the cardiac pump function.
H D Bethge; K Bachmann
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Zeitschrift für Kardiologie     Volume:  72 Suppl 3     ISSN:  0300-5860     ISO Abbreviation:  Z Kardiol     Publication Date:  1983  
Date Detail:
Created Date:  1984-03-21     Completed Date:  1984-03-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0360430     Medline TA:  Z Kardiol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  92-7     Citation Subset:  IM    
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MeSH Terms
Coronary Vasospasm / diagnosis
Coronary Vessels / drug effects*
Ergonovine / diagnostic use*
Hemodynamics / drug effects
Isosorbide Dinitrate / administration & dosage,  pharmacology*
Middle Aged
Nifedipine / administration & dosage,  pharmacology*
Reg. No./Substance:
21829-25-4/Nifedipine; 60-79-7/Ergonovine; 87-33-2/Isosorbide Dinitrate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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