| Assessment of sublingual isosorbide dinitrate and intracoronary nifedipine during ergonovine provocation. | |
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MedLine Citation:
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PMID: 6666236 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In 37 patients with suspected vasospastic angina diagnostic ergonovine testing was used as a method of analysing the efficacy of sublingual ISDN in comparison with sublingual and intracoronary nifedipine on coronary luminal diameter, left ventricular ejection fraction, aortic blood pressure, heart rate and left ventricular end-diastolic pressure. 10 mg of sublingual ISDN counteracted the ergonovine effects on left ventricular pump function and hemodynamics. The luminal diameter of the epicardial coronary arteries increased from 3.5 +/- 0.8 to 4.9 +/- 0.8 mm. 20 mg of sublingual nifedipine did not change the coronary luminal diameter within 8-10 minutes after the ergonovine test. After administration of 0.1 mg of nifedipine into the right and left coronary artery the luminal diameters increased in the same range as after sublingual ISDN. Whereas the aortic blood pressure decreased after intracoronary nifedipine from 170 +/- 23 to 153 +/- 27 mmHg with a concomitant increase in heart rate, no effect on the left ventricular pump function could be assessed. In the model of ergonovine testing ISDN has shown itself as a potent drug in releasing the ergonovine effects. Sublingual ISDN is as potent as intracoronary nifedipine in releasing the ergonovine-induced reduction of coronary luminal diameters and more potent in counteracting the ergonovine effects concerning the cardiac pump function. |
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Authors:
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H D Bethge; K Bachmann |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Zeitschrift für Kardiologie Volume: 72 Suppl 3 ISSN: 0300-5860 ISO Abbreviation: Z Kardiol Publication Date: 1983 |
Date Detail:
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Created Date: 1984-03-21 Completed Date: 1984-03-21 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0360430 Medline TA: Z Kardiol Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 92-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Coronary Vasospasm / diagnosis Coronary Vessels / drug effects* Ergonovine / diagnostic use* Female Hemodynamics / drug effects Humans Isosorbide Dinitrate / administration & dosage, pharmacology* Male Middle Aged Nifedipine / administration & dosage, pharmacology* |
| Chemical | |
Reg. No./Substance:
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21829-25-4/Nifedipine; 60-79-7/Ergonovine; 87-33-2/Isosorbide Dinitrate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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