| Assessment of stratum-covariate interactions in Cox's proportional hazards regression model. | |
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MedLine Citation:
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PMID: 3515475 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We assess stratum (e.g. treatment) interactions with covariates and with the baseline hazard function in the proportional hazards (PH) regression model for lifetime data. We consider models incorporating stratum interactions both with and without stratification of the risk sets in the likelihood function, and describe likelihood ratio statistics for tests of the presence of these interactions. We also present step-down methods for building reduced models which include stratum-specific parameters corresponding to covariates which interact with treatment. We apply PH models with such interactions to a clinical trial of DES in the treatment of prostate cancer to determine optimal treatment conditional on each patient's covariates. |
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Authors:
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P F Thall; J M Lachin |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Statistics in medicine Volume: 5 ISSN: 0277-6715 ISO Abbreviation: Stat Med Publication Date: 1986 Jan-Feb |
Date Detail:
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Created Date: 1986-05-14 Completed Date: 1986-05-14 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8215016 Medline TA: Stat Med Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 73-83 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Biometry* Clinical Trials as Topic Diethylstilbestrol / administration & dosage Humans Male Prostatic Neoplasms / drug therapy Random Allocation Regression Analysis |
| Grant Support | |
ID/Acronym/Agency:
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N01-AM02205/AM/NIADDK NIH HHS; R01-AM27769-02/AM/NIADDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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56-53-1/Diethylstilbestrol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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