Document Detail


Assessment of stratum-covariate interactions in Cox's proportional hazards regression model.
MedLine Citation:
PMID:  3515475     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We assess stratum (e.g. treatment) interactions with covariates and with the baseline hazard function in the proportional hazards (PH) regression model for lifetime data. We consider models incorporating stratum interactions both with and without stratification of the risk sets in the likelihood function, and describe likelihood ratio statistics for tests of the presence of these interactions. We also present step-down methods for building reduced models which include stratum-specific parameters corresponding to covariates which interact with treatment. We apply PH models with such interactions to a clinical trial of DES in the treatment of prostate cancer to determine optimal treatment conditional on each patient's covariates.
Authors:
P F Thall; J M Lachin
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Statistics in medicine     Volume:  5     ISSN:  0277-6715     ISO Abbreviation:  Stat Med     Publication Date:    1986 Jan-Feb
Date Detail:
Created Date:  1986-05-14     Completed Date:  1986-05-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8215016     Medline TA:  Stat Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  73-83     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Biometry*
Clinical Trials as Topic
Diethylstilbestrol / administration & dosage
Humans
Male
Prostatic Neoplasms / drug therapy
Random Allocation
Regression Analysis
Grant Support
ID/Acronym/Agency:
N01-AM02205/AM/NIADDK NIH HHS; R01-AM27769-02/AM/NIADDK NIH HHS
Chemical
Reg. No./Substance:
56-53-1/Diethylstilbestrol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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