Document Detail

[Assessment of the strategies to improve therapeutic compliance in routine clinical practice in noncompliant patients with Alzheimer-type dementia].
MedLine Citation:
PMID:  22234564     Owner:  NLM     Status:  In-Data-Review    
INTRODUCTION AND AIM. The potential benefits of the therapy for patients with chronic diseases such as Alzheimer's disease depends largely on adherence to the treatment. The main objective of this study was to assess which of the strategies used by physicians in clinical practice were effective in improving adherence in noncompliant patients with Alzheimer-type dementia (ATD). PATIENTS AND METHODS. An epidemiological, multicenter, observational, prospective, study in non-compliant patients with diagnosis of ATD with a baseline assessment and two follow-up visits at three and at six months. The primary outcome was treatment adherence in the last month. Patients who had missed more than 20% of the prescribed doses or who had failed to have the doses in the time, dose or dosage form prescribed by the physician in more than 20% of the cases were considered as non-compliant. RESULTS. The first cause of non-adherence was forgetfulness, followed by the caregiver burden. Overall, the use of one or more strategies to improve adherence was effective. The percentage of non-adherent patients was reduced to 26% at three months and up to 14% at six months. CONCLUSION. The modification of treatment for Alzheimer's disease psychoeducation are effective interventions to reduce treatment failure in patients with ATD.
J L Molinuevo; F J Arranz
Publication Detail:
Type:  English Abstract; Journal Article    
Journal Detail:
Title:  Revista de neurologia     Volume:  54     ISSN:  1576-6578     ISO Abbreviation:  Rev Neurol     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-01-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7706841     Medline TA:  Rev Neurol     Country:  Spain    
Other Details:
Languages:  spa     Pagination:  65-73     Citation Subset:  IM    
Fundacion Dr. Esteve, 08032 Barcelona, Espana.
Vernacular Title:
Evaluacion de las estrategias para mejorar el cumplimiento terapeutico en la practica clinica habitual en pacientes incumplidores con demencia tipo Alzheimer.
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