Document Detail

Assessment of skin barrier function in podoconiosis: measurement of stratum corneum hydration and transepidermal water loss.
MedLine Citation:
PMID:  23445314     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Podoconiosis is a common cause of lymphoedema in barefoot workers in Ethiopia and other countries. It has severe consequences for patients' physical function, quality of life and economic status.
AIMS: To investigate stratum corneum (SC) hydration and transepidermal water loss (TEWL) in patients with podoconiosis compared with controls.
METHODS: In total, 55 patients and 20 controls were recruited. For each study subject, SC and TEWL measurements were taken, along with foot and lower leg circumferences. Measurements were compared between the patient and control groups.
RESULTS: Foot circumferences tended to be higher in patients with podoconiosis, with the mean foot:leg circumference ratio being 1·19 (95% confidence interval 1·11-1·28) times that for controls (P = 0·001). There was no detectable difference between patients and controls in TEWL values (P > 0·05); however, SC hydration was significantly lower in patients vs. controls for the foot (P = 0·004) and lower leg (P = 0·046) sites.
CONCLUSIONS: Patients with podoconiosis have significantly lower SC hydration in the skin of their lower legs and feet than controls, which may lead to cracking and splitting, and increased risk of lymphoedema and infection.
J S Ferguson; W E Yeshanehe; W Yeshanehe; P J Matts; P Matts; G Davey; P S Mortimer; P Mortimer; L C Fuller; C Fuller
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of dermatology     Volume:  168     ISSN:  1365-2133     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-28     Completed Date:  2013-08-19     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  550-4     Citation Subset:  IM    
Copyright Information:
© 2012 The Authors. BJD © 2012 British Association of Dermatologists.
Department of Dermatology, St George's Hospital, London, UK.
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MeSH Terms
Aged, 80 and over
Case-Control Studies
Elephantiasis / physiopathology*
Epidermis / physiology*
Lymphedema / physiopathology
Middle Aged
Water Loss, Insensible / physiology*
Water-Electrolyte Imbalance / physiopathology
Young Adult
Erratum In:
Br J Dermatol. 2013 Sep;169(3):726
Note: Yeshanehe, W [corrected to Yeshanehe, W E]; Matts, P [ corrected to Matts, P J]; Mortimer, P [corrected to Mortimer, P S]; Fuller, C [corrected to Fuller, L C]

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