| Assessment of the severity of coronary artery disease by thallium-201 washout rate after dipyridamole infusion--a coronary hemodynamic and metabolic study. | |
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MedLine Citation:
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PMID: 7752441 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study examined the relationship between the myocardial washout rate (WR) of thallium-201 (201Tl) in dipyridamole scintigraphy and both coronary flow reserve (CFR) and myocardial lactate extraction rate (LER) after dipyridamole infusion in 31 patients with coronary artery disease (CAD) without myocardial infarction and 16 control patients. Patients with CAD demonstrated significantly lower WR (21 +/- 17 vs 43 +/- 10%, p < 0.001), lower CFR (128 +/- 82 vs 242 +/- 89%, p < 0.001) and lower LER (-2 +/- 20 vs 10 +/- 10%, p < 0.05) than did the control patients. WR was significantly correlated with CFR (r = 0.50, p < 0.001) and LER (r = 0.41, p < 0.01) in all of the patients. CAD patients with dipyridamole-induced chest pain demonstrated significantly lower WR (14 +/- 20 vs 27 +/- 12%, p < 0.05), lower CFR (97 +/- 71 vs 162 +/- 82%, p < 0.05) and lower LER (-13 +/- 21 vs 11 +/- 9%, p < 0.001) than did CAD patients without chest pain. CAD patients with dipyridamole-induced ST depression demonstrated significantly lower WR (14 +/- 20 vs 29 +/- 8%, p < 0.05), lower CFR (105 +/- 79 vs 170 +/- 73%, p < 0.05) and lower LER (-8 +/- 21 vs 11 +/- 10%, p < 0.01) than did CAD patients without ST depression. These results suggest that the myocardial washout rate of 201Tl after dipyridamole infusion reflects the severity of coronary artery disease as assessed by coronary hemodynamics, myocardial metabolism, symptoms and electrocardiography. |
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Authors:
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S Tamoto; T Ishihara; S Kojima; H Hosokawa; T Ohkubo; S Ohtuji; M Fukai; K Takada; I Seki; N Ohsawa |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Japanese circulation journal Volume: 59 ISSN: 0047-1828 ISO Abbreviation: Jpn. Circ. J. Publication Date: 1995 Jan |
Date Detail:
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Created Date: 1995-06-21 Completed Date: 1995-06-21 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7806868 Medline TA: Jpn Circ J Country: JAPAN |
Other Details:
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Languages: eng Pagination: 11-22 Citation Subset: IM |
Affiliation:
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First Department of Internal Medicine, Osaka Medical College, Takatsuki, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angina Pectoris / chemically induced, diagnosis Coronary Circulation / drug effects* Coronary Disease / metabolism, physiopathology, radionuclide imaging* Dipyridamole / administration & dosage, diagnostic use* Electrocardiography Female Heart / radionuclide imaging* Hemodynamics / drug effects Humans Infusions, Intravenous Lactates / metabolism Male Middle Aged Myocardium / metabolism* Regression Analysis Thallium Radioisotopes / diagnostic use* |
| Chemical | |
Reg. No./Substance:
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0/Lactates; 0/Thallium Radioisotopes; 58-32-2/Dipyridamole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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