Document Detail


Assessment of serum creatine kinase among adolescent patients following jimsonweed (Datura stramonium) and moonflower (Datura inoxia) ingestions: a review of 11 cases.
MedLine Citation:
PMID:  20524835     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Datura stramonium (DS) (jimsonweed) is well known for its abuse potential for hallucinogenic effects and Datura inoxia (DI) (moonflower) has been abused for similar effects. To our knowledge, only one case report describes rhabdomyolysis in association with DS or DI ingestion.
CASE IDENTIFICATION AND DETAILS: Patient hospital charts were retrospectively screened from January 1, 2002 to December 31, 2007 to identify patients with qualifying ICD-9 codes for toxic plant ingestions. We report on 11 patient cases of DS/DI ingestions in which serum creatine kinase (CK) concentrations were monitored. These admissions occurred at our hospital over a 6-year period. Serum CK concentrations ranged from 72 to 70,230 U/L. Only three patients had serum CK concentrations greater than 1,000 U/L. One patient with a peak concentration of 70,230 U/L and a positive myoglobinuria was diagnosed with rhabdomyolysis.
DISCUSSION: Based on our review of the literature and these cases, it is possible that serum CK concentrations may be elevated more frequently than previously realized. The clinical significance of this abnormal laboratory value is uncertain with the majority of patients remaining asymptomatic without any clinical evidence of rhabdomyolysis.
Authors:
Martha G Blackford; James J Fitzgibbon; Michael D Reed
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical toxicology (Philadelphia, Pa.)     Volume:  48     ISSN:  1556-9519     ISO Abbreviation:  Clin Toxicol (Phila)     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-30     Completed Date:  2010-07-20     Revised Date:  2013-07-15    
Medline Journal Info:
Nlm Unique ID:  101241654     Medline TA:  Clin Toxicol (Phila)     Country:  England    
Other Details:
Languages:  eng     Pagination:  431-4     Citation Subset:  AIM; IM    
Affiliation:
Divisions of Clinical Pharmacology and Toxicology and the Rebecca D. Considine Clinical Research Institute, Children's Hospital Medical Center of Akron, Akron, OH, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Blood Chemical Analysis
Creatine Kinase / blood*,  diagnostic use
Data Collection
Datura / adverse effects*
Datura stramonium*
Eating
Humans
International Classification of Diseases
Myoglobinuria / complications
Rhabdomyolysis* / blood,  complications,  diagnosis
Substance-Related Disorders / complications*
Chemical
Reg. No./Substance:
EC 2.7.3.2/Creatine Kinase

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