| Assessment of selenium bioavailability from naturally produced high-selenium soy foods in selenium-deficient rats. | |
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MedLine Citation:
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PMID: 21093782 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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We assessed the bioavailability of selenium (Se) from a protein isolate and tofu (bean curd) prepared from naturally produced high-Se soybeans. The Se concentrations of the soybeans, the protein isolate and tofu were 5.2±0.2, 11.4±0.1 and 7.4±0.1mg/kg, respectively. Male weanling Sprague-Dawley rats were depleted of Se by feeding them a 30% Torula yeast-based diet (4.1μg Se/kg) for 56 days, and then they were replenished with Se for an additional 50 days by feeding them the same diet containing 14, 24 or 30 μg Se/kg from the protein isolate or 13, 23 or 31 μg Se/kg from tofu, respectively. l-Selenomethionine (SeMet) was used as a reference. Selenium bioavailability was determined on the basis of the restoration of Se-dependent enzyme activities and tissue Se concentrations in Se-depleted rats, comparing those responses for the protein isolate and tofu to those for SeMet by using a slope-ratio method. Dietary supplementation with the protein isolate or tofu resulted in linear or log-linear, dose-dependent increases in glutathione peroxidase activities in blood and liver and in thioredoxin reductase activity in liver. Furthermore, supplementation with the protein isolate or tofu resulted in linear or log-linear, dose-dependent increases in the Se concentrations of plasma, liver, muscle and kidneys. These results indicated an overall bioavailability of approximately 101% for Se from the protein isolate and 94% from tofu, relative to SeMet. We conclude that Se from naturally produced high-Se soybeans is highly bioavailable in this model and that high-Se soybeans may be a good dietary source of Se. |
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Authors:
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Lin Yan; Philip G Reeves; LuAnn K Johnson |
Publication Detail:
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Type: Journal Article Date: 2010-06-03 |
Journal Detail:
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Title: Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) Volume: 24 ISSN: 1878-3252 ISO Abbreviation: J Trace Elem Med Biol Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-11-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9508274 Medline TA: J Trace Elem Med Biol Country: Germany |
Other Details:
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Languages: eng Pagination: 223-9 Citation Subset: IM |
Copyright Information:
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Published by Elsevier GmbH. |
Affiliation:
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U.S. Department of Agriculture/Agricultural Research Service, Grand Forks Human Nutrition Research Center, 2420 2nd Avenue North, Grand Forks, ND 58202, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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