Document Detail

Assessment of the salt-arterial pressure relationship in mild hypertensive subjects by 24-hour ambulatory monitoring.
MedLine Citation:
PMID:  7874853     Owner:  NLM     Status:  MEDLINE    
1. We have assessed the relationship between salt intake and 24 h ambulatory arterial pressure in middle aged men with essential hypertension. 2. During the run-in phase (1 month) we estimated the habitual sodium intake (the average Na excretion of two 24 h urine collections) of each participant (n = 14). In the randomized and crossover part of the study we contemplated a 'habitual' sodium intake phase, in which each individual received a fixed diet (about 30 mmol of Na+ and 65 mmol of K+) with additional salt so as to equalize the average intake of the run-in phase, as well as high sodium phases (habitual intake +50 and +100 mmol/day) and low sodium phases (habitual intake -50 and -100 mmol/day). After the trial, 10 patients underwent an additional week of fixed salt intake to assess the reproducibility of 24 h ambulatory monitoring. 3. Average 24 h arterial pressure at habitual sodium intake was significantly lower than that at high intake and significantly higher than at low sodium intake. Clinic arterial pressure showed similar trends but only systolic pressure changes at low sodium intake achieved statistical significance. 4. Analysis of the data on an individual basis showed a linear increase in 24 h mean arterial pressure with increasing levels of sodium intake in all but two cases (flat response in one case and a non-linear rise in the other case). The response pattern of clinic measurements was much less homogeneous. In the aggregate, there was a highly significant linear trend for ambulatory arterial pressure to rise with increasing levels of salt intake.(ABSTRACT TRUNCATED AT 250 WORDS)
C Zoccali; F Mallamaci; D Leonardis
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  87     ISSN:  0143-5221     ISO Abbreviation:  Clin. Sci.     Publication Date:  1994 Dec 
Date Detail:
Created Date:  1995-04-05     Completed Date:  1995-04-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  635-9     Citation Subset:  IM    
Divisione di Nefrologia e CNR Centro di Fisiologia Clinica, Reggio Cal, Italy.
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MeSH Terms
Blood Pressure Monitoring, Ambulatory*
Calcium / urine
Cross-Over Studies
Dose-Response Relationship, Drug
Hypertension / physiopathology*,  urine
Middle Aged
Sodium / urine
Sodium Chloride, Dietary / administration & dosage*
Reg. No./Substance:
0/Sodium Chloride, Dietary; 7440-23-5/Sodium; 7440-70-2/Calcium

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