Document Detail

Assessment of river contamination by estrogenic compounds in Paris area (France).
MedLine Citation:
PMID:  15081696     Owner:  NLM     Status:  MEDLINE    
Wastewater treatment plants (WWTPs) receive a large spectrum of endocrine disrupting compounds (EDCs) that are partially eliminated during treatment processes and discharged into rivers. Given the lack of information in France about river contamination by EDCs, we chose to examine estrogenic potential of WWTP influents, effluents and receiving waters in Paris and its suburbs. Water samples were analyzed using gas chromatography coupled with mass spectrometry for quantifying natural and synthetic estrogens combined with an in vitro estrogenicity bioassay associated to a high pressure liquid chromatography fractionation. The four estrogens investigated, Estrone (E1), 17beta-Estradiol (E2), Estriol (E3) and 17alpha-Ethinylestradiol (EE2) were found in all WWTP and river samples at concentrations ranging from 2.7 to 17.6 ng/l and 1.0 to 3.2 ng/l, respectively. The synthetic estrogen EE2 seems more resistant to biodegradation in WWTPs and thus accounted for 35-50% of the estimated estrogenic activity in rivers. However, fractionation of samples and differences between concentrations of E1, E2, E3 and EE2 and the estrogenic activity measured by the in vitro bioassay suggested a complexity of mechanisms underlying the biological response that could not be attributed only to the investigated molecules.
Maëlle Cargouët; Daniel Perdiz; Asmaa Mouatassim-Souali; Sara Tamisier-Karolak; Yves Levi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Science of the total environment     Volume:  324     ISSN:  0048-9697     ISO Abbreviation:  Sci. Total Environ.     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-04-14     Completed Date:  2004-06-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0330500     Medline TA:  Sci Total Environ     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  55-66     Citation Subset:  IM    
Laboratoire Santé Publique-Environnement, EA 3542, Université Paris XI-Faculté de Pharmacie, 5 rue Jean-Baptiste Clément, 92 296 Châtenay-Malabry Cedex, France.
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MeSH Terms
Biodegradation, Environmental
Biological Assay
Breast Neoplasms / pathology
Chromatography, High Pressure Liquid
Environmental Monitoring
Estrogens / analysis,  metabolism,  toxicity*
Gas Chromatography-Mass Spectrometry
Tumor Cells, Cultured
Waste Disposal, Fluid
Water Pollutants, Chemical / analysis,  metabolism,  toxicity*
Reg. No./Substance:
0/Estrogens; 0/Water Pollutants, Chemical

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