| Assessment of river contamination by estrogenic compounds in Paris area (France). | |
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MedLine Citation:
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PMID: 15081696 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Wastewater treatment plants (WWTPs) receive a large spectrum of endocrine disrupting compounds (EDCs) that are partially eliminated during treatment processes and discharged into rivers. Given the lack of information in France about river contamination by EDCs, we chose to examine estrogenic potential of WWTP influents, effluents and receiving waters in Paris and its suburbs. Water samples were analyzed using gas chromatography coupled with mass spectrometry for quantifying natural and synthetic estrogens combined with an in vitro estrogenicity bioassay associated to a high pressure liquid chromatography fractionation. The four estrogens investigated, Estrone (E1), 17beta-Estradiol (E2), Estriol (E3) and 17alpha-Ethinylestradiol (EE2) were found in all WWTP and river samples at concentrations ranging from 2.7 to 17.6 ng/l and 1.0 to 3.2 ng/l, respectively. The synthetic estrogen EE2 seems more resistant to biodegradation in WWTPs and thus accounted for 35-50% of the estimated estrogenic activity in rivers. However, fractionation of samples and differences between concentrations of E1, E2, E3 and EE2 and the estrogenic activity measured by the in vitro bioassay suggested a complexity of mechanisms underlying the biological response that could not be attributed only to the investigated molecules. |
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Authors:
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Maëlle Cargouët; Daniel Perdiz; Asmaa Mouatassim-Souali; Sara Tamisier-Karolak; Yves Levi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Science of the total environment Volume: 324 ISSN: 0048-9697 ISO Abbreviation: Sci. Total Environ. Publication Date: 2004 May |
Date Detail:
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Created Date: 2004-04-14 Completed Date: 2004-06-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0330500 Medline TA: Sci Total Environ Country: Netherlands |
Other Details:
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Languages: eng Pagination: 55-66 Citation Subset: IM |
Affiliation:
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Laboratoire Santé Publique-Environnement, EA 3542, Université Paris XI-Faculté de Pharmacie, 5 rue Jean-Baptiste Clément, 92 296 Châtenay-Malabry Cedex, France. maelle.cargouet@cep.u-psud.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biodegradation, Environmental Biological Assay Breast Neoplasms / pathology Chromatography, High Pressure Liquid Environmental Monitoring Estrogens / analysis, metabolism, toxicity* Gas Chromatography-Mass Spectrometry Humans Paris Rivers Tumor Cells, Cultured Waste Disposal, Fluid Water Pollutants, Chemical / analysis, metabolism, toxicity* |
| Chemical | |
Reg. No./Substance:
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0/Estrogens; 0/Water Pollutants, Chemical |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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