Document Detail

Assessment of right ventricular functions during cancer chemotherapy.
MedLine Citation:
PMID:  21880609     Owner:  NLM     Status:  Publisher    
AIMS: Although systolic and diastolic left ventricular functions after cancer chemotherapy are well studied, there are a few investigations about the right ventricular functions. We aimed to investigate the early effects of chemotherapy on right heart, if any, in addition to the association between N-terminal pro-brain natriuretic peptide (NT-proBNP) and right heart echocardiographic indices. METHODS AND RESULTS: Thirty-seven consecutive patients with newly diagnosed breast cancer who were planned to receive either AC protocol [cyclophosphamide (600 mg/m(2)) + adriamycin (60 mg/m(2))] or CAF protocol [cyclophosphamide (600 mg/m(2)) + adriamycin (60 mg/m(2)) + 5-fluorouracil (600 mg/m(2))] for six cures were enrolled between February 2009 and June 2010. Echocardiography was performed before the onset of the chemotheurapeutic regimen (T1), on the day after the completion of the first cure (T2), and after the completion of two cures of the regimen (T3). Serum NT-proBNP levels were also measured at T1, T2, and T3. The mean right ventricular fractional area change (RVFAC) was 63.7 ± 3.63, 63.3 ± 3.67, and 61.2 ± 4.41% at T1, T2, and T3, respectively (pT1-T3 and pT2-T3 <0.05). Tricuspid annular plane systolic excursion (TAPSE) has decreased in time (1.82 ± 0.2, 1.78 ± 0.19, and 1.62 ± 0.24 cm; pT1-T2, pT1-T3, and pT2-T3 were 0.002, <0.001, and <0.001, respectively). Tricuspid annular mean E'/A' ratios were 1.42 ± 0.16, 1.36 ± 0.18, and 1.11 ± 0.32 (pT1-T2 = 0.013, pT1-T3 < 0.001, and pT2-T3 < 0.001). Mean tricuspid annular systolic velocities were 11.35 ± 1.85, 11.0 ± 1.82, and 10.45 ± 1.75 cm/s for T1, T2, and T3; and the differences between T1 and T2, T1 and T3, and T2 and T3 were all significant (P = 0.005, <0.001, and 0.001). Median serum NT-proBNP levels were 82 (60-247), 116 (60-426), and 170 (60-600) pg/mL at T1, T2, and T3. The amount of change in RVFAC and TAPSE between T1 and T3 were found to be correlated with the amount of change in NT-proBNP measurements between T1 and T3 (R: -0.7, P < 0.001; R: -0.62, P < 0.001). CONCLUSION: There is a subclinical decrease in right ventricular systolic and diastolic echocardiographic indices, although mostly, in the normal range, in a relatively short time interval after onset of chemotherapy.
Asli Tanindi; Umut Demirci; Gulten Tacoy; Suleyman Buyukberber; Yakup Alsancak; Ugur Coskun; Ridvan Yalcin; Mustafa Benekli
Related Documents :
12053309 - Transcatheter closure of muscular ventricular septal defects in two patients after myoc...
17177049 - Intensive care outcome of adult patients operated on for congenital heart disease.
4017979 - Long term treatment of congenital hypothyroidism with l-triiodothyronine: 24 year follo...
9922359 - Cross sectional echocardiographic assessment of the extent of the atrial septum relativ...
8588849 - Complex congenital heart disease, microcephaly, pheochromocytoma and neurofibromatosis ...
14624439 - Novel technique to prevent prolapse of the amplatzer septal occluder through large atri...
11352079 - Possible reasons for the prognostic value of troponin-t on admission in patients with s...
17049639 - Left ventricular epicardial vvi pacing for a congenital complete heart block with sever...
19072879 - Effects of levosimendan on left atrial functions in patients with ischemic heart failure.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-30
Journal Detail:
Title:  European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology     Volume:  -     ISSN:  1532-2114     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-9-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100890618     Medline TA:  Eur J Echocardiogr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Cardiology, Gazi University Faculty of Medicine, Besevler, 06500 Ankara, Turkey.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Determinants of echocardiographic left atrial volume: implications for normalcy.
Next Document:  Contrast enhancement in the phase plate transmission electron microscopy using an objective lens wit...