| Assessment of the right ventricular function in patients with chronic obstructive pulmonary disease using MRI. | |
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MedLine Citation:
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PMID: 21852436 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Background Chronic obstructive pulmonary disease (COPD) is often associated with changes of the structure and the function of the right ventricle (RV). Therefore, the assessment of right ventricular function and myocardial mass (MM) is clinically important for the evaluation of the severity of COPD, which may provide an objective basis for therapeutic strategy. Purpose To assess the right ventricular function and RV MM in patients with mild to severe COPD using magnetic resonance imaging (MRI). Material and Methods We prospectively studied 49 COPD patients determined by the pulmonary function test (PFT). Using the Global Initiative for COPD classification, the COPD patients were divided into three groups according to the severity of the disease: group I = mild (n = 18); group II = moderate (n = 16); and group III = severe (n = 15). The patient groups were compared to a control group consisting of 30 age-matched, healthy, non-smoking subjects. The RV function and RV MM were obtained by 1.5T cardiac MRI in all of the four groups. The results were compared among the four groups using the ANOVA. Pearson's correlation was used to evaluate the relationship between the right ventricular ejection fraction (RVEF) and MM with the PFT results in COPD patients. Results The RVEF was significantly lower in group III than in the other groups (P < 0.01). The RV MM differed significantly among all groups (P < 0.01) and gradually increased with the severity of COPD (P < 0.01). The correlation was significant between the MRI results and forced expiratory volume in 1 s (r = 0.860 for RVEF, r = -0.838 for RV MM) in COPD patients. Conclusion The RVEF and RV MM measured by MRI correlate significantly with the severity of disease as determined by PFT in patients with COPD. |
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Authors:
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Yan Gao; Xiangying Du; Wen Qin; Kuncheng Li |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta radiologica (Stockholm, Sweden : 1987) Volume: 52 ISSN: 1600-0455 ISO Abbreviation: Acta Radiol Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-08-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8706123 Medline TA: Acta Radiol Country: England |
Other Details:
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Languages: eng Pagination: 711-5 Citation Subset: IM |
Affiliation:
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Department of Radiology, Xuanwu Hospital of Capital Medical University, Beijing, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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