| Assessment of right and left ventricular function in healthy mice by blood-pool pinhole gated SPECT. | |
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MedLine Citation:
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PMID: 18722982 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The feasibility of blood-pool pinhole ECG gated SPECT was investigated in healthy mice to assess right and left ventricular function analysis. Anaesthetized (isoflurane 1-1.5%) adult CD1 mice (n=11) were analyzed after intravenous administration of 0.2 ml of 550 MBq of (99m)Tc human albumin. For blood-pool gated SPECT imaging, 48 ventral step and shoot projections with eight time bins per RR over 180 degrees with 64 x 64 word images were acquired with a small animal gamma camera equipped with a pinhole collimator of 12 cm in focal length and 1.5 mm in diameter. For appropriate segmentation of right and left ventricular volumes, a 4D Fourier analysis was performed after reconstruction and reorientation of blood-pool images with a voxel size of 0.55 x 0.55 x 0.55 mm(3). Average right and left ejection fractions were respectively 52+/-4.7% and 65+/-5.2%. Right end diastolic and end systolic volumes were significantly higher compared with the corresponding left ventricular volumes (P<0.0001 each). A linear correlation between right and left stroke volumes (r=0.9, P<0.0001) was obtained and right and left cardiac outputs were not significantly different 14.2+/-1.9 and 14.1+/-2 ml/min, respectively. |
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Authors:
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Christian Goetz; Laurent Monassier; Philippe Choquet; André Constantinesco |
Publication Detail:
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Type: Journal Article Date: 2008-07-01 |
Journal Detail:
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Title: Comptes rendus biologies Volume: 331 ISSN: 1631-0691 ISO Abbreviation: C. R. Biol. Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-08-25 Completed Date: 2008-10-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101140040 Medline TA: C R Biol Country: France |
Other Details:
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Languages: eng Pagination: 637-47 Citation Subset: IM |
Affiliation:
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Service de biophysique et médecine nucléaire, CHU Hautepierre, 1, av. Molière, 67098 Strasbourg, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cardiac Output / physiology Cardiac Volume / physiology Electrocardiography Gated Blood-Pool Imaging / methods* Heart / radionuclide imaging* Heart Atria / radionuclide imaging Heart Rate / physiology Male Mice Reference Values Stroke Volume / physiology Tomography, Emission-Computed, Single-Photon Ventricular Function, Left / physiology* Ventricular Function, Right / physiology* |
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