Document Detail

Assessment of right and left ventricular function in healthy mice by blood-pool pinhole gated SPECT.
MedLine Citation:
PMID:  18722982     Owner:  NLM     Status:  MEDLINE    
The feasibility of blood-pool pinhole ECG gated SPECT was investigated in healthy mice to assess right and left ventricular function analysis. Anaesthetized (isoflurane 1-1.5%) adult CD1 mice (n=11) were analyzed after intravenous administration of 0.2 ml of 550 MBq of (99m)Tc human albumin. For blood-pool gated SPECT imaging, 48 ventral step and shoot projections with eight time bins per RR over 180 degrees with 64 x 64 word images were acquired with a small animal gamma camera equipped with a pinhole collimator of 12 cm in focal length and 1.5 mm in diameter. For appropriate segmentation of right and left ventricular volumes, a 4D Fourier analysis was performed after reconstruction and reorientation of blood-pool images with a voxel size of 0.55 x 0.55 x 0.55 mm(3). Average right and left ejection fractions were respectively 52+/-4.7% and 65+/-5.2%. Right end diastolic and end systolic volumes were significantly higher compared with the corresponding left ventricular volumes (P<0.0001 each). A linear correlation between right and left stroke volumes (r=0.9, P<0.0001) was obtained and right and left cardiac outputs were not significantly different 14.2+/-1.9 and 14.1+/-2 ml/min, respectively.
Christian Goetz; Laurent Monassier; Philippe Choquet; André Constantinesco
Publication Detail:
Type:  Journal Article     Date:  2008-07-01
Journal Detail:
Title:  Comptes rendus biologies     Volume:  331     ISSN:  1631-0691     ISO Abbreviation:  C. R. Biol.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-25     Completed Date:  2008-10-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101140040     Medline TA:  C R Biol     Country:  France    
Other Details:
Languages:  eng     Pagination:  637-47     Citation Subset:  IM    
Service de biophysique et médecine nucléaire, CHU Hautepierre, 1, av. Molière, 67098 Strasbourg, France.
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MeSH Terms
Cardiac Output / physiology
Cardiac Volume / physiology
Gated Blood-Pool Imaging / methods*
Heart / radionuclide imaging*
Heart Atria / radionuclide imaging
Heart Rate / physiology
Reference Values
Stroke Volume / physiology
Tomography, Emission-Computed, Single-Photon
Ventricular Function, Left / physiology*
Ventricular Function, Right / physiology*

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