| Assessment of respiratory mechanics by impulse oscillometry in orthopneic patients with acute left ventricular failure. | |
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MedLine Citation:
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PMID: 20723981 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: This study investigated the respiratory function and mechanics of patients with orthopnea caused by acute left ventricular failure (ALVF). METHODS: The study comprised 40 patients with ALVF and 15 control subjects. All patients underwent lung function tests and impulse oscillometry in both sitting and supine positions. In a subgroup of 22 patients, isosorbide dinitrate was administered and impulse oscillometry was performed 15 minutes later in the supine position. RESULTS: No patient reported dyspnea while seated, and the orthopnea score was 2.9 ± 1.4. Left ventricular ejection fraction was 43% ± 10%. Patients demonstrated restrictive spirometric pattern in the sitting position, whereas functional residual capacity was comparable to that of the control group. In the supine position, all pulmonary volumes decreased, except inspiratory capacity which increased. Respiratory reactance (Xrs5) was higher in patients in both sitting (421.8 ± 630.6%pred vs 147.2 ± 72.8%pred, P = .01) and supine (699.8 ± 699.9%pred vs 251.2 ± 151.6%pred, P ≤ .001) positions. Respiratory resistance (Rrs5) (10.6% ± 17.8% mean decrease) and Xrs5 (17.2% ± 39.4% mean decrease) improved after nitrates administration. Orthopnea was better correlated with Xrs5%pred in the supine position (r = .42, P = .007). Ejection fraction was positively correlated with inspiratory capacity %pred (r = .42, P = .007) in the sitting position. CONCLUSION: Patients with ALVF demonstrated increased respiratory reactance that correlated with orthopnea severity and improved after nitrates administration. |
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Authors:
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Dionisios G Spyratos; Georg P Glattki; Lazaros T Sichletidis; Dimitrios Patakas |
Publication Detail:
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Type: Journal Article Date: 2010-08-17 |
Journal Detail:
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Title: Heart & lung : the journal of critical care Volume: 40 ISSN: 1527-3288 ISO Abbreviation: Heart Lung Publication Date: 2011 Mar-Apr |
Date Detail:
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Created Date: 2011-03-14 Completed Date: 2011-07-21 Revised Date: 2011-10-24 |
Medline Journal Info:
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Nlm Unique ID: 0330057 Medline TA: Heart Lung Country: United States |
Other Details:
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Languages: eng Pagination: 97-104 Citation Subset: AIM; IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Pulmonary, Aristotle University of Thessaloniki, G. Papanicolaou Hospital, Exochi, Thessaloniki, Greece. diospyrato@yahoo.gr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Aged Airway Resistance Case-Control Studies Female Forced Expiratory Volume Health Status Indicators Heart Failure / diagnosis*, pathology Humans Isosorbide Dinitrate / diagnostic use Lung Diseases / diagnosis*, pathology Male Middle Aged Oscillometry / instrumentation* Respiratory Mechanics* Statistics, Nonparametric Stroke Volume Supine Position Vasodilator Agents / diagnostic use Ventricular Function, Left Vital Capacity |
| Chemical | |
Reg. No./Substance:
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0/Vasodilator Agents; 87-33-2/Isosorbide Dinitrate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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