Document Detail

Assessment of residual myocardial viability in regions with chronic electrocardiographic Q-wave infarction.
MedLine Citation:
PMID:  12422157     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Q waves on the electrocardiogram are often considered to be reflective of irreversibly scarred myocardium due to antecedent transmural myocardial infarction. However, there are some indications that residual viable tissue may be present in Q-wave-infarcted regions. It is clinically relevant to know how many Q-wave regions contain viable tissue because these patients may benefit from revascularization in terms of improvement of function and long-term survival. METHODS: Patients (n = 150) with chronic electrocardiographic Q-wave infarction, heart failure symptoms, and chronic coronary artery disease underwent dobutamine-atropine stress echocardiography to assess myocardial viability. Residual viability in regions with Q-wave infarction was considered present when the end-diastolic wall thickness (EDWT) was >6 mm and the response during dobutamine infusion indicated viable tissue. RESULTS: Baseline echocardiography revealed 517 dysfunctional myocardial regions; 202 of the dysfunctional regions were related to Q waves on the electrocardiogram and the other 315 dysfunctional regions were not. EDWT was < or =6 mm in 13 regions with a Q wave on the electrocardiogram, with only 1 region exhibiting viable tissue during dobutamine stress echocardiography. EDWT was >6 mm in 189 regions with a Q wave, with 118 (62%) having viable tissue on dobutamine stress echocardiography. In 6 dysfunctional regions without a Q wave, EDWT was < or =6 mm, with all being nonviable on dobutamine stress echocardiography; of the 309 regions without a Q wave and EDWT >6 mm, 204 (66%) exhibited viability on dobutamine stress echocardiography. CONCLUSIONS: Fifty-eight percent of dysfunctional regions related to chronic Q waves were viable according to the combined information of EDWT and dobutamine stress echocardiography. EDWT </=6 mm virtually excludes viability; regions with EDWT >6 mm need additional testing to detect or exclude viability.
Arend F l Schinkel; Jeroen J Bax; Eric Boersma; Abdou Elhendy; Eleni C Vourvouri; Jos R T C Roelandt; Don Poldermans
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American heart journal     Volume:  144     ISSN:  1097-6744     ISO Abbreviation:  Am. Heart J.     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-11-07     Completed Date:  2002-12-30     Revised Date:  2006-02-27    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  865-9     Citation Subset:  AIM; IM    
Department of Cardiology, Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands.
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MeSH Terms
Cardiac Output, Low / physiopathology,  ultrasonography
Coronary Disease / physiopathology,  ultrasonography
Echocardiography, Stress*
Heart Rate / physiology
Middle Aged
Myocardial Infarction / physiopathology*,  ultrasonography
Stroke Volume / physiology
Tissue Survival*
Ventricular Dysfunction, Left / physiopathology
Comment In:
Am Heart J. 2002 Nov;144(5):745-6   [PMID:  12422139 ]

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