Document Detail

Assessment of reperfusion in myocardial infarction by body surface electrocardiographic mapping.
MedLine Citation:
PMID:  8228717     Owner:  NLM     Status:  MEDLINE    
To determine the efficacy of body surface potential mapping to detect and quantify reperfusion in acute infarction, 66 patients were studied by repeated body surface potential mapping before and after administration of the thrombolytic agent. The QRS and ST-segment were analyzed and compared to the arterial patency as assessed by arteriography within 10 days. The infarct-related vessel was patent in 50 patients and occluded in the remaining 16. In 6 of the 15 patients in whom thrombolytic therapy was started within 2 hours of the onset of chest pain the ST-segment changed from that of an acute infarction pattern to that of a normal pattern, and the QRS pattern either remained normal or recovered prior to discharge. In two additional patients the QRS pattern returned to normal prior to discharge from the hospital. In the 51 patients with later thrombolytic therapy (> or = 2 hours) the degree of ST elevation and depression decreased more than either the control infarction group (36 inferior and 73 anterior patients) or the group in whom reperfusion attempts were unsuccessful, but the pattern of the map remained that of an infarction. The QRS maps showed that in the first 48 hours recovery of potential was insufficient to distinguish those with successful thrombolysis. Early reperfusion could be detected by body surface potential mapping and the eventual damage predicted from the degree of change in the QRS map. Later reperfusion could be surmised but not quantified.
D Kilpatrick; A J Bell; C Briggs
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of electrocardiology     Volume:  26     ISSN:  0022-0736     ISO Abbreviation:  J Electrocardiol     Publication Date:  1993 Oct 
Date Detail:
Created Date:  1993-12-16     Completed Date:  1993-12-16     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0153605     Medline TA:  J Electrocardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  279-89     Citation Subset:  IM    
Department of Medicine, University of Tasmania, Hobart, Australia.
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MeSH Terms
Electrocardiography / methods*
Middle Aged
Myocardial Infarction / diagnosis*,  drug therapy*
Myocardial Reperfusion*
Signal Processing, Computer-Assisted*
Streptokinase / therapeutic use
Thrombolytic Therapy*
Time Factors
Tissue Plasminogen Activator / therapeutic use
Reg. No./Substance:
EC 3.4.-/Streptokinase; EC Plasminogen Activator

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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