Document Detail

Assessment of reperfusion after thrombolytic therapy for myocardial infarction.
MedLine Citation:
PMID:  1636587     Owner:  NLM     Status:  MEDLINE    
The benefits of thrombolytic therapy in reducing the mortality associated with acute myocardial infarction are well documented. Presumably, this is on the basis of a patent IRA, although other mechanisms may be involved. Because there is a 25% to 30% failure rate for thrombolytic therapy that is associated with a significantly worse prognosis, it is crucial to document reperfusion in a timely fashion. In cases of failure to reperfuse, the patient could be considered a candidate for secondary mechanical intervention. While coronary arteriography is presently the "gold standard" to document reperfusion, this is an invasive procedure associated with small but defined risks for the patient. A noninvasive marker that is readily available and highly accurate is most desirable. There are a number of methods currently used to document coronary reperfusion noninvasively. This review discusses the advantages and disadvantages of each method, and the need for continued evaluation and refinement in noninvasive modalities to identify patients who are candidates for further intervention.
A Z Arnold; E J Topol
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  American heart journal     Volume:  124     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1992 Aug 
Date Detail:
Created Date:  1992-08-24     Completed Date:  1992-08-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  441-7     Citation Subset:  AIM; IM    
Department of Cardiology, Cleveland Clinic Foundation, OH 44106.
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MeSH Terms
Clinical Enzyme Tests
Coronary Vessels / physiology
Creatine Kinase / blood
Diagnostic Imaging
Myocardial Infarction / diagnosis,  drug therapy*
Myocardial Reperfusion*
Thrombolytic Therapy*
Vascular Patency / physiology
Reg. No./Substance:
EC Kinase

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