| Assessment of renal hemodynamics and function in pigs with 64-section multidetector CT: comparison with electron-beam CT. | |
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MedLine Citation:
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PMID: 17456868 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To prospectively evaluate the feasibility of obtaining reliable measurements of renal hemodynamics and function by using 64-section multidetector CT. MATERIALS AND METHODS: This study was approved by the Institutional Animal Care and Use Committee. Eight pigs (two with induced unilateral renal artery stenosis) were studied with both electron-beam CT and 64-section multidetector CT at 1-week intervals in randomized order. Both kidneys were scanned repeatedly, without table movement, for about 3 minutes after intravenous (IV) administration of a bolus of contrast medium and again during vasodilator challenge (acetylcholine). Images were reconstructed on each CT console but were analyzed on the same independent workstation. Attenuation changes in the kidneys were plotted as function of time, and time-attenuation curves (TACs) were subsequently analyzed to determine regional perfusion and volume, glomerular filtration rate (GFR), and renal blood flow (RBF). Statistical analysis utilized Student t test, analysis of variance (ANOVA), linear regression, and Bland-Altman analysis. RESULTS: TACs obtained with multidetector CT were qualitatively similar to those obtained with electron-beam CT, as were the quantitative values of renal perfusion and function. RBF correlated significantly between the two techniques (RBF(MD) = 0.96 . RBF(EB) mL/min; R = 0.77, P < .01). GFR(MD) was also similar to GFR(EB) (77.6 +/- 8.3 vs 79.8 +/- 8.8 mL/min, p > .05). Bland-Altman plots showed good agreement between the two techniques. Both techniques similarly detected the differences between stenotic and contralateral kidneys. CONCLUSION: The clinical multidetector CT scanner provides reliable measurements of single-kidney hemodynamics and function, which are similar to those obtained with previously validated electron-beam CT. |
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Authors:
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Elena Daghini; Andrew N Primak; Alejandro R Chade; James D Krier; Xiang-Yang Zhu; Erik L Ritman; Cynthia H McCollough; Lilach O Lerman |
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Publication Detail:
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Type: Comparative Study; Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Radiology Volume: 243 ISSN: 0033-8419 ISO Abbreviation: Radiology Publication Date: 2007 May |
Date Detail:
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Created Date: 2007-04-25 Completed Date: 2007-05-22 Revised Date: 2007-12-03 |
Medline Journal Info:
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Nlm Unique ID: 0401260 Medline TA: Radiology Country: United States |
Other Details:
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Languages: eng Pagination: 405-12 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, Division of Nephrology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Flow Velocity / physiology Electrons / diagnostic use Feasibility Studies Female Glomerular Filtration Rate / physiology* Kidney / blood supply, physiology*, radiography* Kidney Function Tests / methods* Radiographic Image Enhancement / methods Radiographic Image Interpretation, Computer-Assisted / methods* Renal Circulation / physiology* Reproducibility of Results Sensitivity and Specificity Swine Tomography, X-Ray Computed / instrumentation, methods* |
| Grant Support | |
ID/Acronym/Agency:
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DK-73608/DK/NIDDK NIH HHS; HL-72255/HL/NHLBI NIH HHS; HL-77131/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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