| Assessment of renal function in workers previously exposed to cadmium. | |
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MedLine Citation:
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PMID: 3904816 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cadmium induced renal effects were examined in 60 workers (58 men, 2 women) previously exposed to cadmium. Tubular damage in the form of beta 2-microglobulinuria was found in 40%, and urinary albumin and orosomucoid increased significantly with increasing urinary cadmium and increasing relative clearance of beta 2-microglobulin. It is suggested that increased albumin excretion is secondary to the tubular damage. In no case was typical glomerular proteinuria found that could be related to cadmium. Histories of renal stones were more common among the workers with high urinary cadmium concentrations. The glomerular filtration rate was measured in 17 of the workers who had pronounced tubular dysfunction. The average glomerular filtration rate for these men was less than the age adjusted predicted value (mean = 84%). Furthermore, there was a significant (p less than 0.05) correlation (r = -0.47) between tubular reabsorption loss and a decreased glomerular filtration rate. |
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Authors:
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C G Elinder; C Edling; E Lindberg; B Kågedal; O Vesterberg |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: British journal of industrial medicine Volume: 42 ISSN: 0007-1072 ISO Abbreviation: Br J Ind Med Publication Date: 1985 Nov |
Date Detail:
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Created Date: 1985-12-26 Completed Date: 1985-12-26 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0370637 Medline TA: Br J Ind Med Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 754-60 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Albuminuria Cadmium / adverse effects*, urine Female Glomerular Filtration Rate / drug effects Humans Kidney Calculi / chemically induced Kidney Diseases / chemically induced*, physiopathology Kidney Function Tests Male Middle Aged Occupational Diseases / chemically induced*, physiopathology Orosomucoid / urine beta 2-Microglobulin / urine |
| Chemical | |
Reg. No./Substance:
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0/Orosomucoid; 0/beta 2-Microglobulin; 7440-43-9/Cadmium |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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