Document Detail


Assessment of renal function in workers previously exposed to cadmium.
MedLine Citation:
PMID:  3904816     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cadmium induced renal effects were examined in 60 workers (58 men, 2 women) previously exposed to cadmium. Tubular damage in the form of beta 2-microglobulinuria was found in 40%, and urinary albumin and orosomucoid increased significantly with increasing urinary cadmium and increasing relative clearance of beta 2-microglobulin. It is suggested that increased albumin excretion is secondary to the tubular damage. In no case was typical glomerular proteinuria found that could be related to cadmium. Histories of renal stones were more common among the workers with high urinary cadmium concentrations. The glomerular filtration rate was measured in 17 of the workers who had pronounced tubular dysfunction. The average glomerular filtration rate for these men was less than the age adjusted predicted value (mean = 84%). Furthermore, there was a significant (p less than 0.05) correlation (r = -0.47) between tubular reabsorption loss and a decreased glomerular filtration rate.
Authors:
C G Elinder; C Edling; E Lindberg; B Kågedal; O Vesterberg
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of industrial medicine     Volume:  42     ISSN:  0007-1072     ISO Abbreviation:  Br J Ind Med     Publication Date:  1985 Nov 
Date Detail:
Created Date:  1985-12-26     Completed Date:  1985-12-26     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0370637     Medline TA:  Br J Ind Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  754-60     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Albuminuria
Cadmium / adverse effects*,  urine
Female
Glomerular Filtration Rate / drug effects
Humans
Kidney Calculi / chemically induced
Kidney Diseases / chemically induced*,  physiopathology
Kidney Function Tests
Male
Middle Aged
Occupational Diseases / chemically induced*,  physiopathology
Orosomucoid / urine
beta 2-Microglobulin / urine
Chemical
Reg. No./Substance:
0/Orosomucoid; 0/beta 2-Microglobulin; 7440-43-9/Cadmium
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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