| Assessment of renal autoregulation. | |
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MedLine Citation:
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PMID: 17229679 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The kidney displays highly efficient autoregulation so that under steady-state conditions renal blood flow (RBF) is independent of blood pressure over a wide range of pressure. Autoregulation occurs in the preglomerular microcirculation and is mediated by two, perhaps three, mechanisms. The faster myogenic mechanism and the slower tubuloglomerular feedback contribute both directly and interactively to autoregulation of RBF and of glomerular capillary pressure. Multiple experiments have been used to study autoregulation and can be considered as variants of two basic designs. The first measures RBF after multiple stepwise changes in renal perfusion pressure to assess how a biological condition or experimental maneuver affects the overall pressure-flow relationship. The second uses time-series analysis to better understand the operation of multiple controllers operating in parallel on the same vascular smooth muscle. There are conceptual and experimental limitations to all current experimental designs so that no one design adequately describes autoregulation. In particular, it is clear that the efficiency of autoregulation varies with time and that most current techniques do not adequately address this issue. Also, the time-varying and nonadditive interaction between the myogenic mechanism and tubuloglomerular feedback underscores the difficulty of dissecting their contributions to autoregulation. We consider the modulation of autoregulation by nitric oxide and use it to illustrate the necessity for multiple experimental designs, often applied iteratively. |
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Authors:
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William A Cupples; Branko Braam |
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Publication Detail:
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Type: Journal Article; Review Date: 2007-01-16 |
Journal Detail:
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Title: American journal of physiology. Renal physiology Volume: 292 ISSN: 1931-857X ISO Abbreviation: Am. J. Physiol. Renal Physiol. Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-04-05 Completed Date: 2007-05-22 Revised Date: 2011-04-28 |
Medline Journal Info:
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Nlm Unique ID: 100901990 Medline TA: Am J Physiol Renal Physiol Country: United States |
Other Details:
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Languages: eng Pagination: F1105-23 Citation Subset: IM |
Affiliation:
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Centre for Biomedical Research and Dept. of Biology, Univ. of Victoria, PO Box 3020, STN CSC, Victoria, BC, Canada. wcupples@uvic.ca |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Calcium Channel Blockers / pharmacology Feedback Homeostasis* Kidney / blood supply, physiology* Kidney Glomerulus / physiology Kidney Tubules / physiology Muscle, Smooth, Vascular / physiology Nifedipine / pharmacology Nitric Oxide / physiology Rats Renal Circulation / drug effects, physiology* Renin-Angiotensin System / physiology |
| Chemical | |
Reg. No./Substance:
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0/Calcium Channel Blockers; 10102-43-9/Nitric Oxide; 21829-25-4/Nifedipine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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