Document Detail

Assessment of relationship between the pattern of hypertrophy and the function of left ventricle in patients with chronic aortic regurgitation.
MedLine Citation:
PMID:  2141365     Owner:  NLM     Status:  MEDLINE    
Pre- and postoperative echocardiograms of 64 patients with chronic aortic regurgitation who had undergone isolated aortic valvular replacement (AVR) were studied. These patients were divided into 3 groups as follows: (1) Group A patients who had preoperative end-diastolic radius to wall thickness ratio (R/Thd) less than or equal to 3. (2) Group B1 patients who had preoperative R/Thd greater than 3 and end-systolic radius to wall thickness ratio (R/Ths) less than 2. (3) Group B2 patients who had preoperative R/Thd greater than 3 and R/Ths greater than or equal to 2. Using this classification we assessed the relation between the pattern of hypertrophy and left ventricular (LV) function and the reversibility of LV dysfunction following AVR. Preoperatively, ejection fraction (EF) during handgrip exercise was unchanged in Group A (% delta EF: -2.8 +/- 7.1%) and significantly decreased in Groups B1 (-17.0 +/- 5.8%) and B2 (-20.2 +/- 4.6%). In the late postoperative period, however, it was, -1.2 +/- 3.3%, -2.0 +/- 4.6%, and -17.7 +/- 8.6% in Groups A, B1, B2, respectively. Preoperatively the slope of end-systolic wall stress/volume (ESWS-ESV relation was 1.96 +/- 0.43 in Group A (p less than 0.01 vs Group B2, NS vs Group B1), 1.54 +/- 0.38 in Group B1 (NS vs Group B2) and 1.17 +/- 0.47 in Group B2. It was stressed that a good relationship existed between the pattern of hypertrophy and function as well as the reversibility of LV dysfunction following AVR.
H Kasegawa; K Kawazoe; T Fujita; N Nakajima; Y Masuda; Y D Park
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Japanese circulation journal     Volume:  54     ISSN:  0047-1828     ISO Abbreviation:  Jpn. Circ. J.     Publication Date:  1990 Feb 
Date Detail:
Created Date:  1990-07-25     Completed Date:  1990-07-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7806868     Medline TA:  Jpn Circ J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  161-74     Citation Subset:  IM    
Department of Cardiovascular Surgery, National Cardiovascular Center, Osaka, Japan.
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MeSH Terms
Aortic Valve Insufficiency / complications,  physiopathology*,  surgery
Cardiac Volume
Cardiomegaly / etiology,  pathology,  physiopathology*
Chronic Disease
Exercise Test
Heart / physiopathology*
Heart Valve Prosthesis
Middle Aged
Myocardial Contraction
Myocardium / pathology
Stroke Volume

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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