| Assessment of rapid changes in renal blood flow with (191m)Ir, an ultra-short-lived radionuclide. | |
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MedLine Citation:
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PMID: 15001695 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated the feasibility of using (191m)Ir (half-life, 5 s) to measure rapid dynamic alterations in differential renal blood flow. METHODS: A nonobstructive constant renal pelvic pressure model was used. The renal pelves of 6 New Zealand White rabbits were drained by use of bilateral catheters, and increased hydrostatic pressure was achieved by raising 1 catheter to 16, 25, 30, or 35 cm above the level of the renal pelvis. The contralateral kidney served as the control. (191m)Ir first-pass angiograms were obtained at baseline, after the induction of elevated pressure in the renal pelvis, and after the pressure was returned to normal. A minimum of 3 sequential angiograms were obtained at each point. RESULTS: The differential blood flow values (mean +/- SD) were 47.5% +/- 7.3% at baseline, decreased to 42.3% +/- 2.6% when the renal pelvic pressure was elevated (P = 0.001), and returned to 51.1% +/- 4.0% after the pressure was returned to normal (P = 0.0017). There was no significant difference between baseline and postcompression values (P = 0.4807). CONCLUSION: It is possible to use (191m)Ir first-pass angiography to evaluate rapid dynamic changes in differential renal blood flow in an experimental animal model. |
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Authors:
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S Ted Treves; Alan B Packard; Leo C T Fung |
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Publication Detail:
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Type: Comparative Study; Evaluation Studies; Journal Article; Research Support, U.S. Gov't, P.H.S.; Validation Studies |
Journal Detail:
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Title: Journal of nuclear medicine : official publication, Society of Nuclear Medicine Volume: 45 ISSN: 0161-5505 ISO Abbreviation: J. Nucl. Med. Publication Date: 2004 Mar |
Date Detail:
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Created Date: 2004-03-05 Completed Date: 2004-05-13 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0217410 Medline TA: J Nucl Med Country: United States |
Other Details:
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Languages: eng Pagination: 508-11 Citation Subset: IM |
Affiliation:
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Division of Nuclear Medicine, Department of Radiology, Children's Hospital Boston and Harvard Medical School, Boston, Massachusetts 02115, USA. ted.treves@tch.harvard.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Feasibility Studies Iridium / diagnostic use*, pharmacokinetics Isotopes / diagnostic use, pharmacokinetics Kidney / blood supply*, metabolism, radionuclide imaging* Radioisotope Renography / methods* Radiopharmaceuticals / diagnostic use*, metabolism Rats Renal Circulation / physiology* Reproducibility of Results Sensitivity and Specificity |
| Grant Support | |
ID/Acronym/Agency:
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FD-R-000719-06-1/FD/FDA HHS |
| Chemical | |
Reg. No./Substance:
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0/Isotopes; 0/Radiopharmaceuticals; 7439-88-5/Iridium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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