Document Detail

Assessment of rapid changes in renal blood flow with (191m)Ir, an ultra-short-lived radionuclide.
MedLine Citation:
PMID:  15001695     Owner:  NLM     Status:  MEDLINE    
We investigated the feasibility of using (191m)Ir (half-life, 5 s) to measure rapid dynamic alterations in differential renal blood flow. METHODS: A nonobstructive constant renal pelvic pressure model was used. The renal pelves of 6 New Zealand White rabbits were drained by use of bilateral catheters, and increased hydrostatic pressure was achieved by raising 1 catheter to 16, 25, 30, or 35 cm above the level of the renal pelvis. The contralateral kidney served as the control. (191m)Ir first-pass angiograms were obtained at baseline, after the induction of elevated pressure in the renal pelvis, and after the pressure was returned to normal. A minimum of 3 sequential angiograms were obtained at each point. RESULTS: The differential blood flow values (mean +/- SD) were 47.5% +/- 7.3% at baseline, decreased to 42.3% +/- 2.6% when the renal pelvic pressure was elevated (P = 0.001), and returned to 51.1% +/- 4.0% after the pressure was returned to normal (P = 0.0017). There was no significant difference between baseline and postcompression values (P = 0.4807). CONCLUSION: It is possible to use (191m)Ir first-pass angiography to evaluate rapid dynamic changes in differential renal blood flow in an experimental animal model.
S Ted Treves; Alan B Packard; Leo C T Fung
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article; Research Support, U.S. Gov't, P.H.S.; Validation Studies    
Journal Detail:
Title:  Journal of nuclear medicine : official publication, Society of Nuclear Medicine     Volume:  45     ISSN:  0161-5505     ISO Abbreviation:  J. Nucl. Med.     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-03-05     Completed Date:  2004-05-13     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0217410     Medline TA:  J Nucl Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  508-11     Citation Subset:  IM    
Division of Nuclear Medicine, Department of Radiology, Children's Hospital Boston and Harvard Medical School, Boston, Massachusetts 02115, USA.
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MeSH Terms
Feasibility Studies
Iridium / diagnostic use*,  pharmacokinetics
Isotopes / diagnostic use,  pharmacokinetics
Kidney / blood supply*,  metabolism,  radionuclide imaging*
Radioisotope Renography / methods*
Radiopharmaceuticals / diagnostic use*,  metabolism
Renal Circulation / physiology*
Reproducibility of Results
Sensitivity and Specificity
Grant Support
FD-R-000719-06-1/FD/FDA HHS
Reg. No./Substance:
0/Isotopes; 0/Radiopharmaceuticals; 7439-88-5/Iridium

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