Document Detail

Assessment of pulmonary function in amyotrophic lateral sclerosis.
MedLine Citation:
PMID:  19445444     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Amyotrophic lateral sclerosis (ALS) is characterised by diffuse and progressive death of motor neurons and deteriorating pulmonary functions. At diagnosis most patients with ALS usually do not have any respiratory complaints. However, sub-clinical pulmonary dysfunction is known. OBJECTIVE: To study pulmonary dysfunction in patients who clinically and electro-physiologically fulfil El escorial criteria of probable and definite ALS. METHODS: We performed a standard battery of pulmonary function tests (PFTs) including spirometry, maximum voluntary ventilation (MVV) and maximum inspiratory and expiratory pressure (MEP, MIP) on 63 patients fulfilling the El escorial criteria for probable and definite ALS. Results were compared between the El escorial groups, bulbar- and limb-onset ALS and with age- and sex-matched healthy volunteers, taken as controls. RESULTS: Only 11% of the patients had respiratory complaints at diagnosis. There was no statistical difference in pulmonary parameters between bulbar- and limb-onset ALS. The pulmonary dysfunction was restrictive. Both definite and probable ALS patients had significant reduction in all the measured pulmonary function parameters. The reduction in definite ALS patients was greater in forced vital capacity percent (FVC%) predicted, peak expiratory flow rate (PEFR) percent predicted and MIP. The proportion of patients with severe and very severe dysfunction was higher in the definite ALS group as compared to probable ALS group. CONCLUSIONS: Significant pulmonary dysfunction of restrictive type was noted in ALS patients. Both types of ALS, bulbar- and limb-onset, had similar levels of dysfunction.
Sathyaprabha Talakad N; Cauchy Pradhan; Atchayaram Nalini; Kandvel Thennarasu; Trichur R Raju
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Indian journal of chest diseases & allied sciences     Volume:  51     ISSN:  0377-9343     ISO Abbreviation:  Indian J Chest Dis Allied Sci     Publication Date:    2009 Apr-Jun
Date Detail:
Created Date:  2009-05-18     Completed Date:  2009-06-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7612044     Medline TA:  Indian J Chest Dis Allied Sci     Country:  India    
Other Details:
Languages:  eng     Pagination:  87-91     Citation Subset:  IM    
Department of Neurophysiology, National Institute of Mental Health and Neuro Sciences, Bengaluru, India.
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MeSH Terms
Amyotrophic Lateral Sclerosis / physiopathology*
Middle Aged
Respiratory Function Tests

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