Document Detail


Assessment of pulmonary dynamics in normal newborns: a pneumotachographic method.
MedLine Citation:
PMID:  3062157     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A pneumotachographic method for assessment of pulmonary dynamics in critically ill newborns in an intensive care setting was developed in our laboratory. Before the results obtained with this method could be applied, the normal range of values were determined in 48 normal term and preterm newborns. Their body weight ranged between 1200 and 4100 g, and postnatal ages between 24 hours and 21 days. In three infants, two determinations were performed after an interval of 7 days. The studies were performed with a pneumotachograph applied to the upper airway by means of an inflatable face mask or latex nasal prongs. The air flow signal was electronically integrated to time to produce a volume signal. Airway pressure was determined proximal to the pneumotachograph. Esophageal pressure was determined with a water filled catheter placed in the lower third of the esophague. Tidal volume (VT), minute ventilation (V), Dynamic compliance (Cdyn), total pulmonary resistance (R), total pulmonary work (Wt), Elastic work (We), and flow resistive work (Wv), were determined. A significant linear correlation was found between Cdyn and body weight (r = 0.50, p less than 0.01) whereas no significative correlation was found between body weight and VT, V or R. Values for VT, V and Cdyn were corrected for body weight and means (X), standard deviation (SD) so as 10th and 90th percentiles are shown in table III. X, SD and percentiles for R were shown in table III. Wt, We and Wv were corrected for V, and X, SD and percentiles shown in table III. Values of VT/Kg, Cdyn/Kg and R are similar to those found by other authors with pneumotachography and plethysmography. The V/Kg values obtained by us were higher than those reported by other authors, which together with the lack of correlation of VT and V with body weight, question the reliability of V values in our study. This could be explained by: 1) excessive increase in dead space in cases in which a face mask was used; 2) nocioceptive stimulus produced by face mask or nasal prongs; 3) inadequate selection of the moment at which the record was obtained. Whichever the explanation, our values of V cannot be considered as basal, and should be interpreted with caution. The results obtained allow us to continue with our program and apply this method to the study of newborn infants with RDS.
Authors:
P Estol; H Píriz; L Pintos; F Nieto; F Simini
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Publication Detail:
Type:  Comparative Study; Journal Article; Review    
Journal Detail:
Title:  Journal of perinatal medicine     Volume:  16     ISSN:  0300-5577     ISO Abbreviation:  J Perinat Med     Publication Date:  1988  
Date Detail:
Created Date:  1989-02-21     Completed Date:  1989-02-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0361031     Medline TA:  J Perinat Med     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  183-92     Citation Subset:  IM    
Affiliation:
Latin-American Center of Perinatology and Human Development, Montevideo, Uruguay.
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MeSH Terms
Descriptor/Qualifier:
Airway Resistance
Humans
Infant, Newborn / physiology*
Lung / physiology*
Lung Compliance
Respiration
Respiratory Function Tests*
Tidal Volume
Work of Breathing

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