Document Detail


Assessment of proximal tubular sodium reabsorption during water diuresis in patients with heart disease.
MedLine Citation:
PMID:  4392957     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In order to examine the relation between cardiac state and the capacity to excrete a water load, 10 normal subjects and 61 patients with heart disease were studied during water diuresis. Under these conditions, urine flow approximates to the rate of delivery of filtrate, and therefore of sodium, from the proximal tubule of the kidney to the loop of Henle, while free water clearance is a function of distal sodium reabsorption. In 12 patients with complete heart block, ventricular pacing was associated with increased urine flow and free water clearance. Oral propranolol in 3 normal subjects and in 9 patients with intact atrial septa caused a reduction, and oral practolol in 4 normal subjects and 8 patients caused no change. In 6 patients with atrial septal defect, propranolol was without effect. Maximum urine flow correlated with left ventricular end-diastolic pressure but not mean left atrial pressure in 16 patients with chronic rheumatic heart disease. In 7 patients with ischaemic heart disease, maximum urine flow was higher than in those with chronic rheumatic heart disease and similar increase in left ventricular end-diastolic pressure. These results reflect a close relation between proximal tubular sodium reabsorption and cardiac state, and suggest that inappropriate sodium reabsorption at this site may contribute to fluid retention in heart disease.
Authors:
D G Gibson; J C Marshall; E Lockey
Related Documents :
6790017 - Sodium and potassium in essential hypertension.
1946787 - Electrolytes in the epidemiology, pathophysiology, and treatment of hypertension.
6862587 - Epidemiological study of the relationship between calcium and blood pressure.
2168457 - Sodium bicarbonate and sodium chloride: effects on blood pressure and electrolyte homeo...
17928667 - Development of an on-line low gas pressure cell for laser ablation-icp-mass spectrometry.
6933807 - Antihypertensive treatment inhibiting the progression of diabetic nephropathy.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British heart journal     Volume:  32     ISSN:  0007-0769     ISO Abbreviation:  Br Heart J     Publication Date:  1970 May 
Date Detail:
Created Date:  1970-07-29     Completed Date:  1970-07-29     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0370634     Medline TA:  Br Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  399-405     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Acetanilides / therapeutic use
Adrenergic beta-Antagonists
Blood Pressure
Chronic Disease
Coronary Disease / physiopathology
Diuresis*
Heart Block / therapy
Heart Diseases / metabolism*
Heart Septal Defects, Atrial / drug therapy
Humans
Kidney Tubules / metabolism*
Pacemaker, Artificial
Propranolol / therapeutic use
Rheumatic Heart Disease / physiopathology
Sodium / metabolism*
Water-Electrolyte Balance
Chemical
Reg. No./Substance:
0/Acetanilides; 0/Adrenergic beta-Antagonists; 525-66-6/Propranolol; 7440-23-5/Sodium
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The roles of pregn-5-ene-3 beta, 20 alpha-diol and 20 alpha-hydroxy steroid dehydrogenase in the con...
Next Document:  Prejunctional actions of some beta-adrenoreceptor antagonists in the vas deferens preparation of the...