Document Detail

Assessment of proximal tubular sodium reabsorption during water diuresis in patients with heart disease.
MedLine Citation:
PMID:  4392957     Owner:  NLM     Status:  MEDLINE    
In order to examine the relation between cardiac state and the capacity to excrete a water load, 10 normal subjects and 61 patients with heart disease were studied during water diuresis. Under these conditions, urine flow approximates to the rate of delivery of filtrate, and therefore of sodium, from the proximal tubule of the kidney to the loop of Henle, while free water clearance is a function of distal sodium reabsorption. In 12 patients with complete heart block, ventricular pacing was associated with increased urine flow and free water clearance. Oral propranolol in 3 normal subjects and in 9 patients with intact atrial septa caused a reduction, and oral practolol in 4 normal subjects and 8 patients caused no change. In 6 patients with atrial septal defect, propranolol was without effect. Maximum urine flow correlated with left ventricular end-diastolic pressure but not mean left atrial pressure in 16 patients with chronic rheumatic heart disease. In 7 patients with ischaemic heart disease, maximum urine flow was higher than in those with chronic rheumatic heart disease and similar increase in left ventricular end-diastolic pressure. These results reflect a close relation between proximal tubular sodium reabsorption and cardiac state, and suggest that inappropriate sodium reabsorption at this site may contribute to fluid retention in heart disease.
D G Gibson; J C Marshall; E Lockey
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British heart journal     Volume:  32     ISSN:  0007-0769     ISO Abbreviation:  Br Heart J     Publication Date:  1970 May 
Date Detail:
Created Date:  1970-07-29     Completed Date:  1970-07-29     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0370634     Medline TA:  Br Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  399-405     Citation Subset:  AIM; IM    
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MeSH Terms
Acetanilides / therapeutic use
Adrenergic beta-Antagonists
Blood Pressure
Chronic Disease
Coronary Disease / physiopathology
Heart Block / therapy
Heart Diseases / metabolism*
Heart Septal Defects, Atrial / drug therapy
Kidney Tubules / metabolism*
Pacemaker, Artificial
Propranolol / therapeutic use
Rheumatic Heart Disease / physiopathology
Sodium / metabolism*
Water-Electrolyte Balance
Reg. No./Substance:
0/Acetanilides; 0/Adrenergic beta-Antagonists; 525-66-6/Propranolol; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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