Document Detail

Assessment of the presence of occult myocardial infarction in chronic obstructive pulmonary disease using contrast-enhanced cardiac magnetic resonance imaging.
MedLine Citation:
PMID:  19223680     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Chronic obstructive pulmonary disease (COPD) has been identified as a risk factor for ischaemic heart disease, independent of smoking history, and inflammation is thought to play a role. OBJECTIVES: We sought to ascertain whether occult myocardial infarction (MI) was present in the COPD population, and to assess its relationship with inflammation and natriuretic peptides. METHOD: We recruited 25 patients with moderate/severe COPD and 17 control smokers without lung disease. All participants had no known cardiac disease. Contrast-enhanced cardiac magnetic resonance imaging was performed and analysed for delayed contrast enhancement (DE), indicative of previous MI. All participants had venous blood samples taken for assessment of NT-proBNP and inflammatory markers. RESULTS: DE was not found in any participant. Right ventricular ejection fraction was lower in COPD patients. Other cardiac measurements and NT-proBNP levels were similar in the 2 groups. C-reactive protein, IL-8, GM-CSF, IL-1 beta and TNF-alpha were all significantly higher in the COPD group. CONCLUSION: DE, indicating previous MI, was not found in patients with moderate/severe COPD. Occult MI does not appear to be common in this population, but a larger study would be needed to conclusively test this.
C Aengus Murphy; Kevin G Blyth; Rekha Chaudhuri; Jane Lafferty; Eleanor Hothersall; Tracey Steedman; Charles McSharry; Henry J Dargie; Neil C Thomson
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-02-18
Journal Detail:
Title:  Respiration; international review of thoracic diseases     Volume:  78     ISSN:  1423-0356     ISO Abbreviation:  Respiration     Publication Date:  2009  
Date Detail:
Created Date:  2009-09-29     Completed Date:  2010-01-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0137356     Medline TA:  Respiration     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  263-9     Citation Subset:  IM    
Copyright Information:
(c) 2009 S. Karger AG, Basel.
Cardiology Department, Western Infirmary, University of Glasgow, Glasgow, UK.
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MeSH Terms
Biological Markers / blood
Cross-Sectional Studies
Gadolinium DTPA / diagnostic use
Inflammation / blood,  complications*
Magnetic Resonance Imaging
Middle Aged
Myocardial Infarction / blood,  diagnosis,  etiology*
Natriuretic Peptide, Brain / blood*
Peptide Fragments / blood*
Pulmonary Disease, Chronic Obstructive / blood,  complications*
Smoking / adverse effects
Reg. No./Substance:
0/Biological Markers; 0/Peptide Fragments; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain; 80529-93-7/Gadolinium DTPA

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