Document Detail

Assessment of prenatal smoke exposure by determining nicotine and its metabolites in maternal and neonatal urine.
MedLine Citation:
PMID:  11339618     Owner:  NLM     Status:  MEDLINE    
Urine specimens were collected from 75 pregnant women before childbirth and from their newborns within 48 postnatal hours. A high-performance liquid chromatography (HPLC) method was used to determine urinary nicotine and its metabolites, cotinine and trans-3'-hydroxycotinine (OH-cotinine) to objectivise prenatal smoke exposure. Using the sum of nicotine metabolites as a marker, 34 women were classed as not exposed to smoke ( < 15 nmol/l), 18 as passive smokers (15-400 nmol/l), and 23 as active smokers ( > 400 nmol/1). The newborns of active smokers exhibited significantly (P < 0.001) higher nicotine metabolite concentrations than did those of either non-exposed women or passive smokers. A close correlation was found to exist between maternal and neonatal nicotine and cotinine concentrations (r=0.8968 and r=0.9205, respectively). For OH-cotinine, this correlation was particularly close when maternal, but not neonatal, OH - cotinine was adjusted to creatinine (r=0.9792). The neonatal/maternal urine concentration ratios for cotinine and OH-cotinine were noted to not significantly depend on the time of postpartal urine collection. Within the first two postnatal days, the extent of current prenatal smoke exposure attributable to active smoking of the mother was best reflected by the urinary concentrations of cotinine plus OH-cotinine without adjustment to creatinine.
E Köhler; D Bretschneider; A Rabsilber; W Weise; G Jorch
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Human & experimental toxicology     Volume:  20     ISSN:  0960-3271     ISO Abbreviation:  Hum Exp Toxicol     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-05-07     Completed Date:  2001-09-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9004560     Medline TA:  Hum Exp Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1-7     Citation Subset:  IM    
Department of General Paediatrics and Neonatology, Medical Faculty, Otto von Guericke University, Magdeburg, Germany.
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MeSH Terms
Cotinine / urine
Infant, Newborn
Maternal-Fetal Exchange / physiology*
Nicotine / urine*
Nicotinic Agonists / urine*
Smoking / metabolism*
Tobacco Smoke Pollution
Reg. No./Substance:
0/Nicotinic Agonists; 0/Tobacco Smoke Pollution; 486-56-6/Cotinine; 54-11-5/Nicotine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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