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Assessment of the potential genotoxic risk of medicinal Tamarindus indica fruit pulp extract using in vivo assays.
MedLine Citation:
PMID:  19768670     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Tamarindus indica has been used in folk medicine as an antidiabetic, a digestive aid, and a carminative, among other uses. Currently, there is no information in the toxicology literature concerning the safety of T. indica extract. We evaluated the clastogenic and/or genotoxic potential of fruit pulp extract of this plant in vivo in peripheral blood and liver cells of Wistar rats, using the comet assay, and in bone marrow cells of Swiss mice, using the micronucleus test. The extract was administered by gavage at doses of 1000, 1500 and 2000 mg/kg body weight. Peripheral blood and liver cells from Wistar rats were collected 24 h after treatment, for the comet assay. The micronucleus test was carried out in bone marrow cells from Swiss mice collected 24 h after treatment. The extract made with T. indica was devoid of clastogenic and genotoxic activities in the cells of the rodents, when administered orally at these three acute doses.
Authors:
F M V Silva; M F Leite; A C C Spadaro; S A Uyemura; E L Maistro
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2009-9-8
Journal Detail:
Title:  Genetics and molecular research : GMR     Volume:  8     ISSN:  1676-5680     ISO Abbreviation:  Genet. Mol. Res.     Publication Date:  2009  
Date Detail:
Created Date:  2009-9-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101169387     Medline TA:  Genet Mol Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1085-1092     Citation Subset:  -    
Affiliation:
Laboratório de Genética, Universidade José do Rosário Vellano, Alfenas, MG, Brasil.
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