Document Detail


Assessment of postprandial hepatic glycogen synthesis from uridine diphosphoglucose kinetics in obese and lean non-diabetic subjects.
MedLine Citation:
PMID:  11093291     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Obese patients are frequently characterized by insulin resistance and decreased insulin-mediated glycogen synthesis in skeletal muscle. Whether they also have impaired postprandial hepatic glycogen synthesis remains unknown.
AIM: To determine whether postprandial hepatic glycogen synthesis is decreased in obese patients compared to lean subjects.
METHODS: Lean and obese subjects with impaired glucose tolerance were studied over 4h after ingestion of a glucose load. Hepatic uridine diphosphoglucose kinetics were assessed using 13C-galactose infusion, with monitoring of urinary acetaminophen-glucuronide isotopic enrichment to estimate hepatic glycogen kinetics.
RESULTS: Estimated net hepatic glycogen synthesis amounted to 18.6 and 22.6% of the ingested load in lean and obese subjects, respectively.
CONCLUSION: Postprandial hepatic glycogen metabolism is not impaired in non-diabetic obese subjects.
Authors:
N Paquot; P Schneiter; A J Scheen; P J Lefèbvre; L Tappy
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity     Volume:  24     ISSN:  -     ISO Abbreviation:  Int. J. Obes. Relat. Metab. Disord.     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2000-11-29     Completed Date:  2001-05-03     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  9313169     Medline TA:  Int J Obes Relat Metab Disord     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1297-302     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Blood Glucose / analysis
Fatty Acids, Nonesterified / blood
Female
Glucose Intolerance / complications,  metabolism
Humans
Insulin / blood
Insulin Resistance
Liver / metabolism*
Liver Glycogen / biosynthesis*
Male
Middle Aged
Obesity / complications,  metabolism*
Postprandial Period
Time Factors
Uridine Diphosphate Glucose / metabolism,  pharmacokinetics*
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Fatty Acids, Nonesterified; 0/Insulin; 0/Liver Glycogen; V50K1D7P4Y/Uridine Diphosphate Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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