Document Detail

Assessment of plaque rupture by intravascular ultrasound.
MedLine Citation:
PMID:  9476576     Owner:  NLM     Status:  MEDLINE    
To investigate the mechanism of plaque rupture, we carried out morphologic and quantitative assessments of ruptured plaque with a 30-MHz intravascular ultrasound catheter before coronary intervention. Plaque rupture, defined as an echolucent intraplaque area communicating with arterial lumen, was noted in all of 22 patients with coronary artery disease examined in the study. The plaque was eccentric in 16 patients (73%) and in 10 of these 16 patients there was a tear at the margin of the plaque (63%). Calcification was noted in only 6 patients (22%). Plaque area ranged from 8.7 to 44.1 mm2. The ruptured area ranged widely, from 1.0 to 14.0 mm2, and the percent ruptured area also ranged widely, from 3.9% to 50.9%. Fibrous cap was recognized in 20 patients. The thickness of the fibrous cap ranged from 0.1 to 0.6 mm (mean, 0.36 mm) and thinning of the fibrous cap was noted in 16 patients (80%). From these results, we conclude that intravascular ultrasound can provide detailed observations of plaque rupture consistent with pathologic studies. Accordingly, it is a suitable method for evaluation of plaque rupture in vivo. Plaque weakness, due to the presence of atheromatous core, thin fibrous cap, and no calcification, seems to be the major determinant of plaque rupture. In addition, the great variation in cap thickness and ruptured area suggests the role of other triggers, such as mechanical and hemodynamic stress, in plaque rupture.
M Moriuchi; S Saito; Y Takaiwa; J Honye; T Fukui; K Horiuchi; T Takayama; J Yajima; T Shimizu; M Chiku; K Komaki; N Tanigawa; Y Ozawa; K Kanmatsuse
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Heart and vessels     Volume:  Suppl 12     ISSN:  0910-8327     ISO Abbreviation:  Heart Vessels     Publication Date:  1997  
Date Detail:
Created Date:  1998-04-07     Completed Date:  1998-04-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8511258     Medline TA:  Heart Vessels     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  178-81     Citation Subset:  IM    
Second Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan.
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MeSH Terms
Coronary Artery Disease / pathology,  ultrasonography*
Coronary Vessels / pathology,  ultrasonography*
Middle Aged
Ultrasonography, Interventional*

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